Sequestosome 1/p62: across diseases

被引：38

作者：

Geetha, Thangiah ^{[1
]}

Vishwaprakash, Nilmini ^{[1
]}

Sycheva, Marina ^{[1
]}

Babu, Jeganathan Ramesh ^{[1
]}

机构：

[1] Auburn Univ, Dept Nutr Dietet & Hospitality Management, Auburn, AL 36849 USA

来源：

BIOMARKERS | 2012年 / 17卷 / 02期

关键词：

Neurodegenerative diseases; cancer; Paget's disease of bone; obesity; insulin resistance; AUTOPHAGY-DEFICIENT MICE; BINDING PROTEIN P62; NF-KAPPA-B; TRANSCRIPTION FACTOR NRF2; CAUSE PAGETS-DISEASE; UBIQUITIN-BINDING; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLES; DEUBIQUITINATING ENZYME; PARKINSONS-DISEASE;

D O I：

10.3109/1354750X.2011.653986

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance. In this review, we will focus on the most recent advances on the physiological function of p62 relevant to human diseases.

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页码：99 / 103

页数：5

相关论文

共 68 条

[1] Ubiquitin, cellular inclusions and their role in neurodegeneration [J].

Alves-Rodrigues, A ;

Gregori, L ;

Figueiredo-Pereira, ME .

TRENDS IN NEUROSCIENCES, 1998, 21 (12) :516-520

[2] Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration [J].

Babu, J. Ramesh ;

Seibenhener, M. Lamar ;

Peng, Junmin ;

Strom, Anna-Lena ;

Kemppainen, Robert ;

Cox, Nancy ;

Zhu, Haining ;

Wooten, Michael C. ;

Diaz-Meco, Maria T. ;

Moscat, Jorge ;

Wooten, Marie W. .

JOURNAL OF NEUROCHEMISTRY, 2008, 106 (01) :107-120

[3] Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation [J].

Babu, JR ;

Geetha, T ;

Wooten, MW .

JOURNAL OF NEUROCHEMISTRY, 2005, 94 (01) :192-203

[4] The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation [J].

Bardag-Gorce, F ;

Riley, NE ;

Nan, L ;

Montgomery, RO ;

Li, J ;

French, BA ;

Lue, YH ;

French, SW .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2004, 76 (01) :9-16

[5] Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases [J].

Braak, Heiko ;

Thal, Dietmar R. ;

Del Tredici, Kelly .

JOURNAL OF NEURAL TRANSMISSION, 2011, 118 (05) :809-819

[6] Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB [J].

Brummelkamp, TR ;

Nijman, SMB ;

Dirac, AMG ;

Bernards, R .

NATURE, 2003, 424 (6950) :797-801

[7] Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone [J].

Cavey, J. R. ;

Ralston, S. H. ;

Sheppard, P. W. ;

Ciani, B. ;

Gallagher, T. R. A. ;

Long, J. E. ;

Searle, M. S. ;

Layfield, R. .

CALCIFIED TISSUE INTERNATIONAL, 2006, 78 (05) :271-277

[8] The effect of acarbose on insulin sensitivity in subjects with impaired glucose tolerance [J].

Chiasson, JL ;

Josse, RG ;

Leiter, LA ;

Mihic, M ;

Nathan, DM ;

Palmason, C ;

Cohen, RM ;

Wolever, TMS .

DIABETES CARE, 1996, 19 (11) :1190-1193

[9] Acarbose for prevention of type 2 diabetes mellitus: the STOPNIDDM randomised trial [J].

Chiasson, JL ;

Josse, RG ;

Gomis, R ;

Hanefeld, M ;

Karasik, A ;

Laakso, M .

LANCET, 2002, 359 (9323) :2072-2077

[10] Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway [J].

Copple, Ian M. ;

Lister, Adam ;

Obeng, Akua D. ;

Kitteringham, Neil R. ;

Jenkins, Rosalind E. ;

Layfield, Robert ;

Foster, Brian J. ;

Goldring, Christopher E. ;

Park, B. Kevin .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (22) :16782-16788

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