The in vivo delivery of heterologous proteins by microencapsulated recombinant cells

被引：58

作者：

Chang, PL ^{[1
]}

Van Raamsdonk, JM

Hortelano, G

Barsoum, SC

MacDonald, NC

Stockley, TL

机构：

[1] McMaster Univ, Dept Pediat, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Med Sci, Hamilton, ON, Canada

[3] McMaster Univ, Dept Pathol, Hamilton, ON, Canada

[4] McMaster Univ, Dept Biol, Hamilton, ON, Canada

[5] Canadian Red Cross, Hamilton, ON, Canada

来源：

TRENDS IN BIOTECHNOLOGY | 1999年 / 17卷 / 02期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0167-7799(98)01250-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery, A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

引用

页码：78 / 83

页数：8

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