Cloning and expression of a rat brain basic helix-loop-helix factor

被引：10

作者：

Kawakami, H

Maruyama, H

Yasunami, M

Ohkubo, H

Hara, H

Saida, T

Nakanishi, S

Nakamura, S

机构：

[1] KUMAMOTO UNIV,SCH MED,INST MOLEC EMBRYOL & GENET,KUMAMOTO 862,JAPAN

[2] NATL UTANO HOSP,DEPT NEUROL,KYOTO 616,JAPAN

[3] NATL UTANO HOSP,CLIN RES CTR,KYOTO 616,JAPAN

[4] KYOTO UNIV,FAC MED,INST IMMUNOL,KYOTO 606,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 221卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.0569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We cloned two rat cDNAs of brain basic helix-loop-helix factor 1 (BHF1). These have an identical coding region, contain 357 amino acids and exhibit 94.6% identity to MATH-2/NEX1 in the basic helix-loop-helix region. BHF1mRNAs are dominantly expressed in the brain, particularly in the cerebellum, in the adult bovine, rat and mouse. Two shorter BHF1mRNAs (1.6 kb and 1.8 kb) were also detected in the mouse embryo, and these decreased in the developmental process. These results suggest that BHF1 may play important roles in cerebellum-specific functions and development of neurons. (C) 1996 Academic Press, Inc.

引用

页码：199 / 204

页数：6

共 16 条

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