Herpesviruses in brains in Alzheimer's and Parkinson's diseases

被引：104

作者：

Hemling, N

Röyttä, M

Rinne, J

Pöllänen, P

Broberg, E

Tapio, V

Vahlberg, T

Hukkanen, V

机构：

[1] Univ Turku, Dept Virol, FIN-20520 Turku, Finland

[2] Univ Turku, MediCity Res Lab, FIN-20520 Turku, Finland

[3] Univ Turku, Dept Pathol, FIN-20520 Turku, Finland

[4] Univ Turku, Dept Neurol, FIN-20520 Turku, Finland

[5] Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland

[6] Univ Turku, Dept Biostat, FIN-20520 Turku, Finland

来源：

ANNALS OF NEUROLOGY | 2003年 / 54卷 / 02期

关键词：

D O I：

10.1002/ana.10662

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the association of HSV-1, HHV-6, and VZV with Alzheimer's disease (AD) and Parkinson's disease (PD). Brain specimens for viral DNA polymerase chain reaction represented 34 patients with AD, 40 with PD, and 40 controls. One AD patient (2.9%) was positive for HSV-1 DNA, 88.2% for HHV-6 DNA, and 26.5% for VZV DNA, 17.5% of PD patients were HSV-1 DNA-positive and 75% HHV-6-positive, whereas 40% had VZV DNA. Twenty-five percent of the controls were positive for HSV-1 DNA, 87.5% for HHV-6, and 27.5% for VZV. HSV-1, VZV, or HHV-6 DNA in brains was no additional risk factor for AD.

引用

收藏

页码：267 / 271

页数：5

相关论文

共 20 条

[1] RAPID DIAGNOSIS OF HERPES-SIMPLEX ENCEPHALITIS BY NESTED POLYMERASE CHAIN-REACTION ASSAY OF CEREBROSPINAL-FLUID [J].

AURELIUS, E ;

JOHANSSON, B ;

SKOLDENBERG, B ;

STALAND, A ;

FORSGREN, M .

LANCET, 1991, 337 (8735) :189-192

[2] HSV-1 in brain and risk of Alzheimer's disease [J].

Beffert, U ;

Bertrand, P ;

Champagne, D ;

Gauthier, S ;

Poirier, J .

LANCET, 1998, 351 (9112) :1330-1331

[3] Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis [J].

Broberg, E ;

Setälä, N ;

Röyttä, M ;

Salmi, A ;

Erälinna, JP ;

He, B ;

Roizman, B ;

Hukkanen, V .

GENE THERAPY, 2001, 8 (10) :769-777

[4] HUMAN HERPESVIRUS-6 DNA IN PERIPHERAL-BLOOD CELLS AND SALIVA FROM IMMUNOCOMPETENT INDIVIDUALS [J].

CONE, RW ;

HUANG, MLW ;

ASHLEY, R ;

COREY, L .

JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (05) :1262-1267

[5] HUMAN HERPES-VIRUS INFECTIONS AND ALZHEIMERS-DISEASE [J].

DEATLY, AM ;

HAASE, AT ;

FEWSTER, PH ;

LEWIS, E ;

BALL, MJ .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1990, 16 (03) :213-223

[6] DETECTION OF VARICELLA-ZOSTER VIRUS-SPECIFIC DNA-SEQUENCES IN CEREBROSPINAL-FLUID FROM PATIENTS WITH ACUTE ASEPTIC-MENINGITIS AND NO CUTANEOUS LESIONS [J].

ECHEVARRIA, JM ;

CASAS, I ;

TENORIO, A ;

DEORY, F ;

MARTINEZMARTIN, P .

JOURNAL OF MEDICAL VIROLOGY, 1994, 43 (04) :331-335

[7]

Glorioso Joseph C., 1995, P1, DOI 10.1016/B978-012397570-6/50003-4

[8] Time-resolved fluorometry PCR assay for rapid detection of herpes simplex virus in cerebrospinal fluid [J].

Hukkanen, V ;

Rehn, T ;

Kajander, R ;

Sjöroos, M ;

Waris, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (09) :3214-3218

[9] Herpes simplex virus type 1 in brain and risk of Alzheimer's disease [J].

Itzhaki, RF ;

Lin, WR ;

Shang, DH ;

Wilcock, GK ;

Faragher, B ;

Jamieson, GA .

LANCET, 1997, 349 (9047) :241-244

[10] LATENT HERPES-SIMPLEX VIRUS TYPE-1 IN NORMAL AND ALZHEIMERS-DISEASE BRAINS [J].

JAMIESON, GA ;

MAITLAND, NJ ;

WILCOCK, GK ;

CRASKE, J ;

ITZHAKI, RF .

JOURNAL OF MEDICAL VIROLOGY, 1991, 33 (04) :224-227