CHAPERONES A story of thrift unfolds

被引：8

作者：

Baneyx, Francois ^{[1
]}

Nannenga, Brent L. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

来源：

NATURE CHEMICAL BIOLOGY | 2010年 / 6卷 / 12期

基金：

美国国家科学基金会;

关键词：

MOLECULAR CHAPERONES; PROTEIN; MACHINES; DNAK;

D O I：

10.1038/nchembio.468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although members of the Hsp70-DnaK family of heat shock proteins are involved in nearly all aspects of cell physiology, some mechanistic details of their mode of action remain obscure. A new substrate helps establish DnaK as an unfoldase that requires as little as five ATP molecules to drive the refolding of one protein.

引用

页码：880 / 881

页数：2

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