Reply to T. W. Bentley: Limitations of the s(E+N) and Related Equations

被引：54

作者：

Mayr, Herbert ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 16期

关键词：

electrophilicity; kinetics; linear free-energy relationships; nucleophilicity; solvent effects; PLUS N) EQUATION; NUCLEOPHILICITY PARAMETERS; DIARYLCARBENIUM IONS; PI-NUCLEOPHILES; SCALE; REACTIVITIES; WATER;

D O I：

10.1002/anie.201007923

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple and unambiguous: In the equation log k=s(E+N), the nucleophilicity N is obtained through the intercepts on the abscissa of linear log k versus E (electrophilicity) correlations. This approach places nucleophiles that differ by more than 30 orders of magnitude in reactivity on a single scale that can be used as a guide for designing organic syntheses. The equation in question is not only more practical but is also more precise than Bentley's alternatives. (Figure Presented) © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3612 / 3618

页数：7

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