Family History and Risk of Recurrent Stroke

被引：29

作者：

Chung, Jong-Won ^{[1
]}

Kim, Beom Joon ^{[2
]}

Han, Moon-Ku ^{[2
]}

Kang, Kyusik ^{[3
]}

Park, Jong-Moo ^{[3
]}

Park, Sang-Soon ^{[4
]}

Park, Tai Hwan ^{[4
]}

Cho, Yong-Jin ^{[5
]}

Hong, Keun-Sik ^{[5
]}

Lee, Kyung Bok ^{[6
]}

Kim, Jae Guk ^{[7
]}

Ko, Youngchai ^{[7
]}

Lee, SooJoo ^{[7
]}

Nah, Hyun-Wook ^{[8
]}

Kim, Dae-Hyun ^{[8
]}

Cha, Jae-Kwan ^{[8
]}

Oh, Mi-Sun ^{[9
]}

Yu, Kyung-Ho ^{[9
]}

Lee, Byung-Chul ^{[9
]}

Jang, Myung Suk ^{[2
]}

Lee, Ji Sung ^{[10
]}

Lee, Juneyoung ^{[11
]}

Bae, Hee-Joon

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Cerebrovasc Ctr, Dept Neurol, Songnam, South Korea

[3] Eulji Univ, Eulji Gen Hosp, Dept Neurol, Seoul, South Korea

[4] Seoul Med Ctr, Dept Neurol, Seoul, South Korea

[5] Inje Univ, Ilsan Paik Hosp, Dept Neurol, Goyang, South Korea

[6] Soonchunhyang Univ Hosp, Dept Neurol, Seoul, South Korea

[7] Eulji Univ, Eulji Univ Hosp, Dept Neurol, Daejeon, South Korea

[8] Dong A Univ Hosp, Dept Neurol, Pusan, South Korea

[9] Hallym Univ, Sacred Heart Hosp, Dept Neurol, Anyang, South Korea

[10] Asan Med Ctr, Clin Res Ctr, Seoul, South Korea

[11] Korea Univ, Coll Med, Dept Biostat, 73 Inchon Ro, Seoul 136701, South Korea

来源：

STROKE | 2016年 / 47卷 / 08期

关键词：

ischemia; prognosis; proportional hazard models; risk assessment; stroke; ACUTE ISCHEMIC-STROKE; PREMATURE CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; VASCULAR-DISEASE; ASSOCIATION; METAANALYSIS; POPULATION; OUTCOMES; SUBTYPE; EVENTS;

D O I：

10.1161/STROKEAHA.116.013148

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-The association between family history of stroke and stroke recurrence remains unclear. Methods-Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and >= 70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke. Results-Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients. Conclusions-This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.

引用

页码：1990 / 1996

页数：7

共 34 条

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