Down-regulation of the CD62L antigen as a possible mechanism for neutrophilia during inflammation

被引：23

作者：

Rogowski, O

Sasson, Y

Kassirer, M

Zeltser, D

Maharshak, N

Arber, N

Halperin, P

Serrov, J

Sorkin, P

Eldor, A

Berliner, S ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, IL-64239 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Emergency Med, IL-64239 Tel Aviv, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Gen Intens Care, IL-64239 Tel Aviv, Israel

[5] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Haematol, IL-64239 Tel Aviv, Israel

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 101卷 / 04期

关键词：

CD62L; L-selectin; leucocyte adhesion molecules; inflammation; CD11b/CD18;

D O I：

10.1046/j.1365-2141.1998.00768.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expressions of both the CD11b/CD18 and CD62L (L-selectin) antigens as well as the absolute number of white blood cells in the peripheral circulating pool of blood in 116 patients with various inflammatory conditions were determined. A highly significant (P<0.0001) negative correlation (r=-0.57) was noted between the absolute number of peripheral blood polymorphonuclear leucocytes and the expression of the CD62L antigen on their surface. In view of the role of CD62L antigen in the rolling of leucocytes along endothelial cells in the microvasculature, its downregulation might explain, at least in part, the demargination and appearance of neutrophilia during inflammation.

引用

页码：666 / 669

页数：4

共 11 条

[1] LEUKOKINETIC STUDIES .4. TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS [J].