Upregulation of CXCL10 in Human Dorsal Root Ganglia during Experimental and Natural Varicella-Zoster Virus Infection

被引：41

作者：

Steain, Megan ^{[1
,2
]}

Gowrishankar, Kavitha ^{[2
]}

Rodriguez, Michael ^{[3
]}

Slobedman, Barry ^{[2
]}

Abendroth, Allison ^{[1
,2
]}

机构：

[1] Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2006, Australia

[2] Westmead Millennium Inst, Ctr Virus Res, Sydney, NSW, Australia

[3] Sydney SW Area Hlth Serv, Dept Forens Med, Sydney, NSW, Australia

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 01期

基金：

英国医学研究理事会;

关键词：

HERPES-SIMPLEX; EXPRESSION; CELLS; GENE;

D O I：

10.1128/JVI.01816-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Varicella-zoster virus (VZV) reactivation causes herpes zoster, which is accompanied by an influx of lymphocytes into affected ganglia, but the stimulus for this infiltrate is not known. We report that VZV infection of ganglia leads to increased CXCL10 production in vitro, in an explant ganglion model and in naturally infected dorsal root ganglia (DRG) during herpes zoster. Lymphocytes expressing the receptor for CXCL10, CXCR3, were also observed throughout naturally infected ganglia during herpes zoster, including immediately adjacent to neurons. This study identifies VZV-induced CXCL10 as a potential driver of T lymphocyte recruitment into DRG during herpes zoster.

引用

收藏

页码：626 / 631

页数：6

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