Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin

被引:12
作者
Soares, JC [1 ]
van Dyck, CH [1 ]
Tan, PZ [1 ]
Zoghbi, SS [1 ]
Garg, P [1 ]
Soufer, R [1 ]
Baldwin, RM [1 ]
Fujita, M [1 ]
Staley, JK [1 ]
Fu, X [1 ]
Amici, L [1 ]
Seibyl, J [1 ]
机构
[1] Yale Univ, Sch Med, VA Connecticut Healthcare Syst, Dept Psychiat, W Haven, CT 06516 USA
关键词
reproducibility; serotonin; 5-HT2A receptors; receptor imaging; neuroimaging; brain imaging;
D O I
10.1016/S0925-4927(01)00071-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The test/retest reproducibility of brain measures of 5-HT2A receptors with positron emission tomography (PET) and [F-18]deuteroaltanserin was examined in a group of eight healthy human subjects. PET measures of 5-HT2A receptors were obtained under an equilibrium paradigm, with a 40-min PET acquisition starting approximately at 300 min (308 +/- 11 min) after bolus plus constant infusion of the radiotracer. Three brain outcome measures were obtained at equilibrium, V-3 (ratio of specific brain uptake to free parent plasma concentration of radiotracer), V-3' (ratio of specific brain uptake to total parent plasma concentration) and RT (ratio of specific to non-displaceable brain uptakes). V-3' and RT had high test/retest reproducibility, as measured by mean intra-sudject% change for cortical brain areas of 14.1 and 11.0%, respectively. They also had high reliability, as measured by mean intra-class correlation coefficients (ICC) for cortical brain areas of 0.86 and 0.88, respectively. V-3 had low test/retest reproducibility, due to high variability in the measures of free parent tracer in plasma. This study supports the feasibility of equilibrium imaging of 5-HT2A receptors with PET and [F-18]deuteroaltanserin. The equilibrium imaging, method with [F-18]deuteroaltanserin allows a single acquisition and blood measurement to provide an image whose pixel values equal a receptor volume of distribution. Since the single image pixel values are proportional to receptor densities, the images can be used in pixel-by-pixel statistical methods, such as SPM, to assess the distribution and density of 5-HT2A receptors in neuropsychiatric disorders. (C) 2001 Published by Elsevier Science Ireland Ltd.
引用
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页码:81 / 93
页数:13
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