Establishment and characterization of a mantle cell lymphoma cell line

被引：68

作者：

Jeon, HJ

Kim, CW

Yoshino, T

Akagi, T ^{[1
]}

机构：

[1] Okayama Univ, Sch Med, Dept Pathol 2, Okayama 7008558, Japan

[2] Chosun Univ, Sch Med, Kwangju 501759, South Korea

[3] Seoul Natl Univ, Sch Med, Dept Pathol, Seoul, South Korea

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 102卷 / 05期

关键词：

mantle cell lymphoma; large cell variant; PRAD1/cyclin D1; cell line; CD5;

D O I：

10.1046/j.1365-2141.1998.00911.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A mantle cell lymphoma (MCL) cell line (JeKo-1) established from peripheral blood mononuclear cells of a patient with a large cell variant of MCL showing leukaemic conversion. JeKo-1 cells were Epstein-Barr virus negative and showed a B-cell phenotype with IgM(+), IgD(+), CD3(-), CD5(+), CD10(-), CD19(+), CD20(+) and CD23(-); they overexpressed cyclin D1, Bcl-2, c-Myc and Rb proteins. Bcl-1/J(H) gene rearrangement was confirmed by polymerase chain reaction, although karyotypic analysis showed 40/41 chromosomes devoid of apparent t(11;14)(q13;q32) translocation. JeKo-1 cells were highly tumourigenic in SCID mice.

引用

页码：1323 / 1326

页数：4

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