Misoprostol: Pharmacokinetic profiles, effects on the uterus and side-effects

被引：233

作者：

Tang, O. S. ^{[1
]}

Gemzell-Danielsson, K. ^{[2
]}

Ho, P. C. ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Peoples R China

[2] Karolinska Univ Hosp, Karolinska Inst, Dept Woman & Child Hlth, Div Obstet & Gynaecol, Stockholm, Sweden

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2007年 / 99卷

关键词：

pharmacokinetics; misoprostol; uterus; side effects;

D O I：

10.1016/j.ijgo.2007.09.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Misoprostol, a synthetic prostaglandin El analogue, is commonly used for medical abortion, cervical priming, the management of miscarriage, induction of labor and the management of postpartum hemorrhage. It can be given orally, vaginally, sublingually, buccally or rectally. Studies of misoprostol's pharmacokinetics and effects on uterine activity have demonstrated the properties of the drug after various routes of administration. These studies can help to discover the optimal. dose and route of administration of misoprostol for individual clinical applications. Misoprostol is a safe drug but serious complications and teratogenicity can occur with unsupervised use. (C) 2007 International Federation of Gynecologyand Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：S160 / S167

页数：8

共 40 条

[1] The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration [J].

Abdel-Aleem, H ;

Villar, J ;

Gülmezoglu, AM ;

Mostafa, SA ;

Youssef, AA ;

Shokry, M ;

Watzer, B .

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2003, 108 (01) :25-28

[2] The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy [J].

Aronsson, A ;

Ulfgren, AK ;

Ståbi, B ;

Stavreus-Evers, A ;

Gemzell-Danielsson, K .

CONTRACEPTION, 2005, 72 (01) :33-39

[3] Effects of misoprostol on uterine contractility following different routes of administration [J].

Aronsson, A ;

Bygdeman, M ;

Gemzell-Danielsson, K .

HUMAN REPRODUCTION, 2004, 19 (01) :81-84

[4] Buccal versus intravaginal misoprostol administration for cervical ripening [J].

Carlan, SJ ;

Blust, D ;

O'Brien, WF .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (02) :229-233

[5] Introduction of the dilation and evacuation procedure for second-trimester abortion in Vietnam using manual vacuum aspiration and buccal misoprostol [J].

Castleman, Laura D. ;

Oanh, Khuat Thi Hai ;

Hyman, Alyson G. ;

Thuy, Le Thanh ;

Blumenthal, Paul D. .

CONTRACEPTION, 2006, 74 (03) :272-276

[6]

Chong YS, 2001, BRIT J OBSTET GYNAEC, V108, P41

[7] Direct transport of progesterone from vagina to uterus [J].

Cicinelli, E ;

de Ziegler, D ;

Bulletti, C ;

Matteo, MG ;

Schonauer, LM ;

Galantino, P .

OBSTETRICS AND GYNECOLOGY, 2000, 95 (03) :403-406

[8] Use of Misoprostol Before Hysteroscopy: A Systematic Review [J].

Crane, Joan M. G. ;

Healey, Sarah .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2006, 28 (05) :373-379

[9] Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial [J].

Derman, Richard J. ;

Kodkany, Bhalchandra S. ;

Goudar, Shivaprasad S. ;

Geller, Stacie E. ;

Naik, Vijaya A. ;

Bellad, M. B. ;

Patted, Shobhana S. ;

Patel, Ashlesha ;

Edlavitch, Stanley A. ;

Hartwell, Tyler ;

Chakraborty, Hrishikesh ;

Moss, Nancy .

LANCET, 2006, 368 (9543) :1248-1253

[10] CERVICAL PRIMING WITH PROSTAGLANDIN-E1 ANALOGS, MISOPROSTOL AND GEMEPROST [J].

ELREFAEY, H ;

CALDER, L ;

WHEATLEY, DN ;

TEMPLETON, A .

LANCET, 1994, 343 (8907) :1207-1209

← 1 2 3 4 →