Cardiovascular actions of CRH and urocortin: an update

被引：94

作者：

Parkes, DG

Weisinger, RS

May, CN

机构：

[1] Amylin Pharmaceut Inc, San Diego, CA 92121 USA

[2] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3052, Australia

来源：

PEPTIDES | 2001年 / 22卷 / 05期

关键词：

urocortin; CRH; hemodynamics; appetite; sheep;

D O I：

10.1016/S0196-9781(01)00396-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urocortin is a potent regulator of cardiac function, with actions that are prolonged in experimental animals. These changes are mediated via binding to CRH receptors found in peripheral tissues. The diversity of actions of urocortin on behaviour, appetite, inflammation and the cardiovascular system suggest that this peptide may be an endogenous factor mediating actions previously attributed to CRH. The present review will focus on the recent understanding of mechanisms mediating the cardiovascular actions of urocortin and CRH reported to date. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：821 / 827

页数：7

共 46 条

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