The coupling of the relative movement of the a and c subunits of the F-0 to the conformational changes in the F-1-ATPase

被引：19

作者：

Howitt, SM

Rodgers, AJW

Hatch, LP

Gibson, F

Cox, GB

机构：

[1] Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National Unversity, Canberra, ACT 2601

[2] Institute of Molecular Biology, University of Oregon, Eugene

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1996年 / 28卷 / 05期

关键词：

F0F1-ATPase; rotation; a-; b-; and; c-subunits;

D O I：

10.1007/BF02113983

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

F0F1-ATPase structural information gained from X-ray crystallography and electron microscopy has activated interest in a rotational mechanism for the F0F1-ATPase. Because of the subunit stoichiometry and the involvement of both the a- and c-subunits in the mechanism of proton movement, it is argued that relative movement must occur between the subunits. Various options for the arrangement and structure of the subunits involved are discussed and a mechanism proposed.

引用

页码：415 / 420

页数：6

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