Type I secretion and multidrug efflux: transport through the TolC channel-tunnel

被引：64

作者：

Buchanan, SK ^{[1
]}

机构：

[1] Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0968-0004(00)01733-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of TolC from Escherichia coli was recently determined to 2.1-Angstrom resolution and shows a unique type of channel architecture: a 12-stranded beta -barrel spans the outer membrane and is attached to a long alpha -helical channel that penetrates far into the periplasm,The structure suggests a mechanism for its role in secretion of proteins and in efflux of toxic small molecules, The TolC export pathway is compared with several import pathways of Gram-negative bacteria where the outer membrane protein structures are also known.

引用

页码：3 / 6

页数：4

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