Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma

被引：18

作者：

Fujieda, S ^{[1
]}

Tanaka, N ^{[1
]}

Sunaga, H ^{[1
]}

Noda, I ^{[1
]}

Sugimoto, C ^{[1
]}

Tsuzuki, H ^{[1
]}

Saito, H ^{[1
]}

机构：

[1] Fukui Med Univ, Dept Otorhinolaryngol, Fukui 9101193, Japan

来源：

CANCER LETTERS | 1998年 / 132卷 / 1-2期

关键词：

hMSH2; mismatch repair protein; CDDP; chemosensitivity; head and neck cancer;

D O I：

10.1016/S0304-3835(98)00157-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the expression of hMSH2, a human mutS homologue from chromosome 2p, in oral and oropharyngeal squamous cell carcinoma (SCC) by an immunohistochemical technique and performed tumor in vitro chemosensitivity testing. In 58 oral and oropharyngeal SCC, the hMSH2 positive score was inversely associated with tumor size, but not with other clinical parameters. Among five anticancer drugs (cisplatin (CDDP), 5-FU, peplomycin, mitomycin C and doxorubicin), only for CDDP was sensitivity to cytotoxicity correlated with the hMSH2 positive score. The susceptibility of hMSH2-positive tumors to CDDP killing was significantly higher than that of hMSH2-negative tumors. Immunohistochemical results regarding hMSH2 are promising in the evaluation of the sensitivity of cancer cells to CDDP cytotoxicity and enable one to select patients for adjuvant chemotherapy for oral and oropharyngeal SCC. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：37 / 44

页数：8

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