The Drosophila protein Wunen repels migrating germ cells

被引：172

作者：

Zhang, N

Zhang, JP

Purcell, KJ

Cheng, Y

Howard, K

机构：

[1] ROCHE INST MOL BIOL, ROCHE RES CTR, NUTLEY, NJ 07110 USA

[2] JACKSON LAB, BAR HARBOR, ME 04609 USA

[3] MERCK SHARP & DOHME RES LABS, DEPT VIRUS & CELL BIOL, W POINT, PA 19486 USA

[4] YALE UNIV, SCH MED, BOYER CTR MOL MED, DEPT CELL BIOL, NEW HAVEN, CT 06536 USA

[5] YALE UNIV, SCH MED, BOYER CTR MOL MED, DEPT BIOL, NEW HAVEN, CT 06536 USA

[6] UNIV NOTRE DAME, DEPT BIOL SCI, NOTRE DAME, IN 46556 USA

[7] UCL, MOL CELL BIOL LAB, LONDON WC1E 6BT, ENGLAND

来源：

NATURE | 1997年 / 385卷 / 6611期

关键词：

D O I：

10.1038/385064a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

IN Drosophila, germ cells migrate in embryonic development from the lumen of the developing gut towards the overlying mesoderm, where they enter the gonads(1,2). The gene wunen is responsible for guiding the germ cells early in this process(3). Here we report that the protein Wunen has two properties that allow it to use repulsion to guide the germ cells. Wunen can transform a permissive cellular environment into a repulsive one, and is expressed in the gut in a pattern that guides germ cells towards the mesoderm. Wunen shows strong similarity to the enzyme type 2 phosphatidic acid phophatase (PAP2)(4), suggesting that it is involved in lipid metabolism.

引用

页码：64 / 67

页数：4

共 23 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2]

BRAND AH, 1993, DEVELOPMENT, V118, P401

[3]

BROOKMAN JJ, 1992, DEVELOPMENT, V116, P1185

[4] POLE CELL-MIGRATION THROUGH THE GUT WALL OF THE DROSOPHILA EMBRYO - ANALYSIS OF CELL-INTERACTIONS [J].