VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism

被引：673

作者：

Bayram, Oezguer ^{[1
]}

Krappmann, Sven ^{[1
]}

Ni, Min ^{[2
,3
]}

Bok, Jin Woo ^{[4
,5
]}

Helmstaedt, Kerstin ^{[1
,6
]}

Valerius, Oliver ^{[1
]}

Braus-Stromeyer, Susanna ^{[1
]}

Kwon, Nak-Jung ^{[2
,3
]}

Keller, Nancy P. ^{[4
,5
]}

Yu, Jae-Hyuk ^{[2
,3
]}

Braus, Gerhard H. ^{[1
]}

机构：

[1] Univ Gottingen, Inst Microbiol & Genet, D-37077 Gottingen, Germany

[2] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Plant Pathol, Madison, WI 53706 USA

[5] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

[6] Res Ctr Mol Physiol Brain CMPB, Deutsch Forschungsgemeinschaft DFG, D-37077 Gottingen, Germany

来源：

SCIENCE | 2008年 / 320卷 / 5882期

关键词：

D O I：

10.1126/science.1155888

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.

引用

页码：1504 / 1506

页数：4

共 26 条

[1] Asexual sporulation in Aspergillus nidulans [J].

Adams, TH ;

Wieser, JK ;

Yu, JH .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (01) :35-+

[2] Secondary metabolic gene cluster silencing in Aspergillus nidulans [J].

Bok, Jin Woo ;

Noordermeer, Daan ;

Kale, Shubha P. ;

Keller, Nancy P. .

MOLECULAR MICROBIOLOGY, 2006, 61 (06) :1636-1645

[3] LaeA, a regulator of secondary metabolism in Aspergillus spp. [J].

Bok, JW ;

Keller, NP .

EUKARYOTIC CELL, 2004, 3 (02) :527-535

[4]

Brakhage AA, 1997, FEMS MICROBIOL LETT, V148, P1

[5]

Braus GH, 2002, MYCOLOGY S, V15, P215

[6] The COP9 signalosome is an essential regulator of development in the filamentous fungus Aspergillus nidulans [J].

Busch, S ;

Eckert, SE ;

Krappmann, S ;

Braus, GH .

MOLECULAR MICROBIOLOGY, 2003, 49 (03) :717-730

[7] An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation [J].

Busch, Silke ;

Schwier, Elke U. ;

Nahlik, Krystyna ;

Bayram, Ozgur ;

Helmstaedt, Kerstin ;

Draht, Oliver W. ;

Krappmann, Sven ;

Valerius, Oliver ;

Lipscomb, William N. ;

Braus, Gerhard H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) :8089-8094

[8] Relationship between secondary metabolism and fungal development [J].

Calvo, AM ;

Wilson, RA ;

Bok, JW ;

Keller, NP .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (03) :447-+

[9] A homologue of the Aspergillus velvet gene regulates both cephalosporin C biosynthesis and hyphal fragmentation in Acremonium chrysogenum [J].

Dreyer, Jacqueline ;

Eichhorn, Heiko ;

Friedlin, Ernst ;

Kuernsteiner, Hubert ;

Kueck, Ulrich .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (10) :3412-3422

[10] CDI1, A HUMAN G1-PHASE AND S-PHASE PROTEIN PHOSPHATASE THAT ASSOCIATES WITH CDK2 [J].

GYURIS, J ;

GOLEMIS, E ;

CHERTKOV, H ;

BRENT, R .

CELL, 1993, 75 (04) :791-803

← 1 2 3 →