Effects of 2-guanidine-4-methylquinazoline on gastric acid secretion in rats

被引：13

作者：

Pinelli, A

Trivulzio, S

Pojaga, G

Rossoni, G

机构：

[1] Dept. of Pharmacol., Chemother./M., University of Milan, 20129, Milan

[2] Dept. of Pharmacol., Chemother./M., Milan

来源：

PHARMACOLOGICAL RESEARCH | 1996年 / 34卷 / 5-6期

关键词：

gastric acid secretion; Shay rats; biguanide compounds; cimetedine; anti- H-2-histamine activity;

D O I：

10.1006/phrs.1996.0092

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study 2-guanidine-4-methylquinazoline (2-GMQ) appeared to decrease basal and stimulated gastric acid secretion, while structurally related compounds as dimethyl-biguanide, cyanoguanidine and 2-cyanoamino-4-methylpyrymidine did not. Thus, there is an antisecretory effect when the biguanide group is associated with a lipophilic structure. The antisecretive effects exerted by 2-GMQ are associated with anti H-2-histamine activity. The anti H-2-histamine nature of the effects of 2-GMQ was confirmed by the capacity of this compound of depressing the chronotropic activity of the isolated guinea pig auricle increased by histamine, as well as relaxant activity in rat uterus contracted by histamine, since both preparations are rich in H-2-histamine receptors. (C) 1996 The Italian Pharmacological Society.

引用

页码：225 / 230

页数：6

共 14 条

[1] SOME QUANTITATIVE USES OF DRUG ANTAGONISTS [J].