The Role of Synovial Macrophages and Macrophage-Produced Mediators in Driving Inflammatory and Destructive Responses in Osteoarthritis

被引:458
作者
Bondeson, Jan
Blom, Arjen B. [2 ]
Wainwright, Shane
Hughes, Clare
Caterson, Bruce [1 ]
van den Berg, Wim B. [2 ]
机构
[1] Cardiff Univ, Cardiff Sch Biosci, Connect Tissue Biol Labs, Cardiff CF10 3US, S Glam, Wales
[2] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands
来源
ARTHRITIS AND RHEUMATISM | 2010年 / 62卷 / 03期
关键词
INTERLEUKIN-1 RECEPTOR ANTAGONIST; KAPPA-B-ALPHA; ADENOVIRAL GENE-TRANSFER; IN-VIVO DELIVERY; RHEUMATOID-ARTHRITIS; KNEE OSTEOARTHRITIS; INTRAARTICULAR INJECTION; CARTILAGE DEGRADATION; SPINAL OSTEOARTHRITIS; OSTEOPHYTE FORMATION;
D O I
10.1002/art.27290
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
[No abstract available]
引用
收藏
页码:647 / 657
页数:11
相关论文
共 81 条
[1]
Biologics in development for rheumatoid arthritis: Relevance to osteoarthritis [J].
Abramson, Steven B. ;
Yazici, Yusuf .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (02) :212-225
[2]
Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IκBα reveals that most, but not all, inflammatory and destructive mediators are NFκB dependent [J].
Amos, N. ;
Lauder, S. ;
Evans, A. ;
Feldmann, M. ;
Bondeson, J. .
RHEUMATOLOGY, 2006, 45 (10) :1201-1209
[3]
Heterogeneous requirement of IκB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis -: Implications for therapy [J].
Andreakos, E ;
Smith, C ;
Kiriakidis, S ;
Monaco, C ;
de Martin, R ;
Brennan, FM ;
Paleolog, E ;
Feldmann, M ;
Foxwell, BM .
ARTHRITIS AND RHEUMATISM, 2003, 48 (07) :1901-1912
[4]
Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type IIIL-1 decoy receptor - Potential for pharmacological intervention [J].
Attur, MG ;
Dave, M ;
Cipolletta, C ;
Kang, P ;
Goldring, MB ;
Patel, IR ;
Abramson, SB ;
Amin, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (51) :40307-40315
[5]
Barrera P, 2000, ARTHRITIS RHEUM-US, V43, P1951, DOI 10.1002/1529-0131(200009)43:9<1951::AID-ANR5>3.0.CO
[6]
2-K
[7]
Synovial tissue inflammation in early and late osteoarthritis [J].
Benito, MJ ;
Veale, DJ ;
Fitzgerald, O ;
van den Berg, WB ;
Bresnihan, B .
ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (09) :1263-1267
[9]
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis [J].
Blom, AB ;
van Lent, PLEM ;
Holthuysen, AEM ;
van der Kraan, PM ;
Roth, J ;
van Rooijen, N ;
van den Berg, WB .
OSTEOARTHRITIS AND CARTILAGE, 2004, 12 (08) :627-635
[10]
Cytokine targeting in osteoarthritis [J].
Blom, Arjen B. ;
van der Kraan, Peter M. ;
van den Berg, Wim B. .
CURRENT DRUG TARGETS, 2007, 8 (02) :283-292