Asymmetric synthesis of cis-5-tert-butylproline with metal carbenoid NH insertion

被引：63

作者：

Davis, FA ^{[1
]}

Yang, B ^{[1
]}

Deng, JH ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 13期

关键词：

D O I：

10.1021/jo030081s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly stereoselective intramolecular metal carbenoid insertion reaction of sulfinimine-derived delta-amino delta-diazoesters is used to prepare cis-5-tert-butylproline. A concerted or nearly concerted metal carbenoid N-H insertion reaction mechanism is proposed.

引用

页码：5147 / 5152

页数：6

共 23 条

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