Enhancement of short-term synaptic plasticity by prior environmental stress

被引:11
作者
Barclay, JW [1 ]
Robertson, RM [1 ]
机构
[1] Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada
关键词
D O I
10.1152/jn.2001.85.3.1332
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
All chemical synapses can rapidly up- or down-regulate the strength of their connections to reshape the postsynaptic signal, thereby stressing the informational importance of specific neural pathways. It is also true that an organism's environment can exert a powerful influence on all aspects of neural circuitry. We investigated the effect of a prior high-temperature stress on the short-term plasticity of a neuromuscular synapse in the hindleg tibial extensor muscle of Locusta migratoria. We found that the prior stress acted to precondition the synapse by increasing the upper temperature limit for synaptic transmission during a subsequent stressful exposure. As well, preexposure to a stressful high-temperature environment increased short-term facilitation of excitatory junction potentials concurrent with a decrease in excitatory junction potential amplitude and a reduction in its temporal parameters. We conclude that a stressful environment can modify synaptic physiological properties resulting in an enhancement of short-term plasticity of the synapse.
引用
收藏
页码:1332 / 1335
页数:4
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