Cell polarity pathways converge and extend to regulate neural tube closure

被引：21

作者：

Zohn, IE

Chesnutt, CR

Niswander, L

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dev Biol Program, New York, NY USA

[3] Cornell Univ, Sch Med, Weill Grad Sch, Dept Neurosci, New York, NY 10021 USA

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(03)00173-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neural tube defects, such as spinabifida, craniorachischisis and anencephaly, are some of the most common birth defects in humans. Recent studies in mouse model systems suggest that craniorachischisis is associated with mutations in genes that regulate cell polarity. Using Xenopus as a model system, Wallingford and Harland have now shed light on the mechanism by which these pathways affect neural tube closure.

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收藏

页码：451 / 454

页数：4

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