HEMATOLOGY Curing CML with imatinib-a dream come true?

被引：23

作者：

Deininger, Michael ^{[1
]}

机构：

[1] Univ Utah, Div Hematol & Hematol Malignancies, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2011年 / 8卷 / 03期

关键词：

CHRONIC MYELOID-LEUKEMIA; COMPLETE MOLECULAR REMISSION; DISCONTINUATION;

D O I：

10.1038/nrclinonc.2011.17

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Imatinib was discontinued in patients with chronic myeloid leukemia (cMl) who gained a complete molecular response (cMR). of those patients with at least 12 months follow-up, 61% experienced recurrence, all of whom responded to rechallenge. The remaining patients maintained cMR, suggesting that imatinib may 'cure' a small proportion of patients with cMl. © 2011 Macmillan Publishers Limited. All rights reserved.

引用

页码：127 / 128

页数：2

共 10 条

[1] The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease [J].

Bose, S ;

Deininger, M ;

Gora-Tybor, J ;

Goldman, JM ;

Melo, JV .

BLOOD, 1998, 92 (09) :3362-3367

[2] Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia [J].

Druker, Brian J. ;

Guilhot, Francois ;

O'Brien, Stephen G. ;

Gathmann, Insa ;

Kantarjian, Hagop ;

Gattermann, Norbert ;

Deininger, Michael W. N. ;

Silver, Richard T. ;

Goldman, John M. ;

Stone, Richard M. ;

Cervantes, Francisco ;

Hochhaus, Andreas ;

Powell, Bayard L. ;

Gabrilove, Janice L. ;

Rousselot, Philippe ;

Reiffers, Josy ;

Cornelissen, Jan J. ;

Hughes, Timothy ;

Agis, Hermine ;

Fischer, Thomas ;

Verhoef, Gregor ;

Shepherd, John ;

Saglio, Giuseppe ;

Gratwohl, Alois ;

Nielsen, Johan L. ;

Radich, Jerald P. ;

Simonsson, Bengt ;

Taylor, Kerry ;

Baccarani, Michele ;

So, Charlene ;

Letvak, Laurie ;

Larson, Richard A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (23) :2408-2417

[3] Relapse and Late Mortality in 5-Year Survivors of Myeloablative Allogeneic Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia in First Chronic Phase [J].

Goldman, John M. ;

Majhail, Navneet S. ;

Klein, John P. ;

Wang, Zhiwei ;

Sobocinski, Kathleen A. ;

Arora, Mukta ;

Horowitz, Mary M. ;

Rizzo, J. Douglas .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (11) :1888-1895

[4]

GUILHOT F, 2009, BLOOD, V114, pA340

[5]

HUGHES TP, 1971, BLOOD, V116, P3758

[6] BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance [J].

Koptyra, Mateusz ;

Falinski, Rafal ;

Nowicki, Michal O. ;

Stoklosa, Tomasz ;

Majsterek, Ireneusz ;

Nieborowska-Skorska, Margaret ;

Blasiak, Janusz ;

Skorski, Tomasz .

BLOOD, 2006, 108 (01) :319-327

[7] Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial [J].

Mahon, Francois-Xavier ;

Rea, Delphine ;

Guilhot, Joelle ;

Guilhot, Francois ;

Huguet, Francoise ;

Nicolini, Franck ;

Legros, Laurence ;

Charbonnier, Aude ;

Guerci, Agnes ;

Varet, Bruno ;

Etienne, Gabriel ;

Reiffers, Josy ;

Rousselot, Philippe .

LANCET ONCOLOGY, 2010, 11 (11) :1029-1035

[8] Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR [J].

Ross, D. M. ;

Branford, S. ;

Seymour, J. F. ;

Schwarer, A. P. ;

Arthur, C. ;

Bartley, P. A. ;

Slader, C. ;

Field, C. ;

Dang, P. ;

Filshie, R. J. ;

Mills, A. K. ;

Grigg, A. P. ;

Melo, J. V. ;

Hughes, T. P. .

LEUKEMIA, 2010, 24 (10) :1719-1724

[9] Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years [J].

Rousselot, Philippe ;

Huguet, Francoise ;

Rea, Delphine ;

Legros, Laurence ;

Cayuela, Jean Michel ;

Maarek, Odile ;

Blanchet, Odile ;

Marit, Gerald ;

Gluckman, Eliane ;

Reiffers, Josy ;

Gardembas, Martine ;

Mahon, Francois-Xavier .

BLOOD, 2007, 109 (01) :58-60

[10] Minimum viable population size: A meta-analysis of 30 years of published estimates [J].

Traill, Lochran W. ;

Bradshaw, Corey J. A. ;

Brook, Barry W. .

BIOLOGICAL CONSERVATION, 2007, 139 (1-2) :159-166

← 1 →