The actin cytoskeleton: a key regulator of apoptosis and ageing?

被引：331

作者：

Gourlay, CW ^{[1
]}

Ayscough, KR ^{[1
]}

机构：

[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrm1682

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.

引用

页码：583 / U5

页数：8

共 52 条

[1] ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion [J].

Ashworth, SL ;

Southgate, EL ;

Sandoval, RM ;

Meberg, PJ ;

Bamburg, JR ;

Molitoris, BA .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) :F852-F862

[2] Mechanism of actin polymerization in cellular ATP depletion [J].

Atkinson, SJ ;

Hosford, MA ;

Molitoris, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) :5194-5199

[3] Actin: General principles from studies in yeast [J].

Ayscough, KR ;

Drubin, DG .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :129-160

[4] ADF/cofilin and actin dynamics in disease [J].

Bamburg, JR ;

Wiggan, OP .

TRENDS IN CELL BIOLOGY, 2002, 12 (12) :598-605

[5]

Bernstein BW, 2003, J NEUROSCI, V23, P1

[6] Expression and cytogenetic localization of the human SM22 gene (TAGLN) [J].

Camoretti-Mercado, B ;

Forsythe, SM ;

LeBeau, MM ;

Espinosa, R ;

Vieira, JE ;

Halayko, AJ ;

Willadsen, S ;

Kurtz, B ;

Ober, C ;

Evans, GA ;

Thweatt, R ;

Shapiro, S ;

Niu, Q ;

Qin, YM ;

Padrid, PA ;

Solway, J .

GENOMICS, 1998, 49 (03) :452-457

[7] Mitochondrial translocation of cofilin is an early step in apoptosis induction [J].

Chua, BT ;

Volbracht, C ;

Tan, KO ;

Li, R ;

Yu, VC ;

Li, P .

NATURE CELL BIOLOGY, 2003, 5 (12) :1083-1089

[8] NUCLEOTIDE EXCHANGE BETWEEN CYTOSOLIC ATP AND F-ACTIN-BOUND ADP MAY BE A MAJOR ENERGY-UTILIZING PROCESS IN UNSTIMULATED PLATELETS [J].

DANIEL, JL ;

MOLISH, IR ;

ROBKIN, L ;

HOLMSEN, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 156 (03) :677-684

[9] Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro [J].

Du, G ;

Mouithys-Mickalad, A ;

Sluse, FE .

FREE RADICAL BIOLOGY AND MEDICINE, 1998, 25 (09) :1066-1074

[10] Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast [J].

Dumont, P ;

Burton, M ;

Chen, QM ;

Gonos, ES ;

Frippiat, C ;

Mazarati, JB ;

Eliaers, F ;

Remacle, J ;

Toussaint, O .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (03) :361-373

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