From Asia to Europe: Mitochondrial DNA sequence variability in Bulgarians and Turks

被引:146
作者
Calafell, F
Underhill, P
Tolun, A
Angelicheva, D
Kalaydjieva, L
机构
[1] EDITH COWAN UNIV,DEPT HUMAN BIOL,PERTH,WA 6027,AUSTRALIA
[2] UNIV BARCELONA,FAC BIOL,UNITAT ANTROPOL,E-08028 BARCELONA,SPAIN
[3] STANFORD UNIV,SCH MED,DEPT GENET,STANFORD,CA 94305
[4] BOGAZICI UNIV,DEPT BIOL,BEBEK 80815,ISTANBUL,TURKEY
[5] FAC MED,LAB MOLEC PATHOL,SOFIA,BULGARIA
关键词
D O I
10.1111/j.1469-1809.1996.tb01170.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Two hypervariable sequence segments in the control region of mitochondrial DNA were determined in samples of Bulgarians and Turks. The Turkish sample presented a higher degree of internal diversity, in terms of total number of variable nucleotides, as well as in the average pairwise nucleotide difference. Pairwise difference distributions were built for both samples, yielding smooth bell shapes in agreement with the Rogers and Harpending model. The Bulgarian and Turkish data were compared with several European and W. Asian Caucasoid populations (Basques, Tuscans, Sardinians. British, Middle Easterners and Indians). Mean pairwise differences suggest that a demographic expansion occurred sequentially in the Middle East, through Turkey, to the rest of Europe (Bulgaria included). Current mutation rate estimates date this expansion in times ranging between 50000 and 100000 years ago and, thus, would correspond to the arrival of anatomically modern humans in Europe. Sequence trees for segment I show that European and Middle Eastern sequences derived from the reference sequence. Coalescence times for segment I sequences agree with those predicted by pairwise distributions. Genetic trees were constructed between populations and revealed an extreme homogeneity between European samples.
引用
收藏
页码:35 / 49
页数:15
相关论文
共 45 条
  • [1] Ammerman A. J., 1984, NEOLITHIC TRANSITION
  • [2] SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME
    ANDERSON, S
    BANKIER, AT
    BARRELL, BG
    DEBRUIJN, MHL
    COULSON, AR
    DROUIN, J
    EPERON, IC
    NIERLICH, DP
    ROE, BA
    SANGER, F
    SCHREIER, PH
    SMITH, AJH
    STADEN, R
    YOUNG, IG
    [J]. NATURE, 1981, 290 (5806) : 457 - 465
  • [3] Andrews Peter., 1989, Ethnic Groups in the Republic of Turkey, Bd I
  • [4] [Anonymous], 1990, GENETIC DATA ANAL
  • [5] [Anonymous], 1978, ARCHAEOLOGY ANCIENT
  • [6] HUMAN MITOCHONDRIAL-DNA VARIATION AND THE ORIGIN OF BASQUES
    BERTRANPETIT, J
    SALA, J
    CALAFELL, F
    UNDERHILL, PA
    MORAL, P
    COMAS, D
    [J]. ANNALS OF HUMAN GENETICS, 1995, 59 : 63 - 81
  • [7] DRIFT, ADMIXTURE, AND SELECTION IN HUMAN-EVOLUTION - A STUDY WITH DNA POLYMORPHISMS
    BOWCOCK, AM
    KIDD, JR
    MOUNTAIN, JL
    HEBERT, JM
    CAROTENUTO, L
    KIDD, KK
    CAVALLISFORZA, LL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (03) : 839 - 843
  • [8] HIGH-RESOLUTION OF HUMAN EVOLUTIONARY TREES WITH POLYMORPHIC MICROSATELLITES
    BOWCOCK, AM
    RUIZLINARES, A
    TOMFOHRDE, J
    MINCH, E
    KIDD, JR
    CAVALLISFORZA, LL
    [J]. NATURE, 1994, 368 (6470) : 455 - 457
  • [9] MITOCHONDRIAL-DNA AND HUMAN-EVOLUTION
    CANN, RL
    STONEKING, M
    WILSON, AC
    [J]. NATURE, 1987, 325 (6099) : 31 - 36
  • [10] Cavalli-Sforza L. L., 1994, The history and geography of human genes