Coagulation disorders in pregnancy: acquired and inherited thrombophilias

被引：45

作者：

Benedetto, Chiara ^{[1
]}

Marozio, Luca ^{[1
]}

Tavella, Anna Maria ^{[1
]}

Salton, Loredana ^{[1
]}

Grivon, Sara ^{[1
]}

Di Giampaolo, Francesca ^{[1
]}

机构：

[1] Univ Turin, Dept Obstet & Gynaecol, Chair C, High Risk Pregnancy Unit, I-10126 Turin, Italy

来源：

WOMEN'S HEALTH AND DISEASE | 2010年 / 1205卷

关键词：

acquired thrombophilia; inherited thrombophilia; adverse pregnancy outcome; deep venous thrombosis; FACTOR-V-LEIDEN; DEFINITE ANTIPHOSPHOLIPID SYNDROME; INTERNATIONAL CONSENSUS STATEMENT; RECURRENT VENOUS THROMBOEMBOLISM; MOLECULAR-WEIGHT HEPARIN; RISK-FACTORS; CLASSIFICATION CRITERIA; POSTPARTUM PERIOD; WOMEN; PREECLAMPSIA;

D O I：

10.1111/j.1749-6632.2010.05674.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Both acquired and inherited thrombophilias are associated with an increased risk of pregnancy-related venous thromboembolism (VTE) as well as with adverse pregnancy outcome. However, the extension of attributable risk for each thrombophilia and outcome is still a question of debate. Thrombophilias have been investigated in connection with VTE and pregnancy complications such as: recurrent and nonrecurrent early pregnancy loss, late fetal death, placental abruption, fetal growth restriction, and preeclampsia. This review discusses the evidence of association between thrombophilias and pregnancy outcome together with issues as to clinical management and preventive strategies.

引用

页码：106 / 117

页数：12

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