Cancer risk in persons with oral cleft - A population-based study of 8,093 cases

被引:93
作者
Bille, C
Winther, JF
Bautz, A
Murray, JC
Olsen, J
Christensen, K
机构
[1] Univ So Denmark, Inst Publ Hlth, Dept Epidemiol, Ctr Prevent Congenital Malformat, DK-5000 Odense, Denmark
[2] Inst Canc Epidemiol, Copenhagen, Denmark
[3] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA
[4] Univ Aarhus, Danish Epidemiol Sci Ctr, Aarhus, Denmark
关键词
abnormalities; cleft lip; cleft palate; cohort studies; follow-up studies; neoplasms;
D O I
10.1093/aje/kwi132
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors conducted a nationwide study of the occurrence of cancer among 8,093 Danish oral cleft cases born in 1936 through 1998 and followed in the Danish Cancer Registry from 1968 through 1998, a total of 175,863 person-years, to assess a possible association between cancer and oral clefts. Observed and expected numbers of cancers among oral cleft cases were summarized as the overall and as 52 site-specific standardized incidence ratios. The expected overall number of all cancers was 131, but 140 incident cancers were found, corresponding to a standardized incidence ratio of 1.07 (95% confidence interval (CI): 0.90, 1.26). Analyses of the 52 sites for all oral cleft cases and analyses stratified for three cleft subgroups and the two sexes revealed only a few significant associations: an increased occurrence of breast cancer among females born with cleft lip and/or cleft palate (standardized incidence ratio (SIR) = 1.52, 95% CI: 1.05, 2.14), primary brain cancer among females born with cleft palate (SIR = 3.11, 95% CI: 1.14, 6.78), and primary lung cancer among males born with both cleft lip and cleft palate (SIR = 2.49, 95% CI: 1.00, 5.14). The results do not provide evidence for an increased overall cancer risk for individuals born with oral clefts.
引用
收藏
页码:1047 / 1055
页数:9
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