Recent Advances on the Role of Cytokines in Atherosclerosis

被引：484

作者：

Ait-Oufella, Hafid ^{[1
,2
]}

Taleb, Soraya ^{[1
,2
]}

Mallat, Ziad ^{[1
,2
,3
]}

Tedgui, Alain ^{[1
,2
]}

机构：

[1] PARCC INSERM U970, 56 Rue Leblanc, F-75015 Paris, France

[2] Univ Paris 05, Paris, France

[3] Univ Cambridge, Addenbrookes Hosp, Div Cardiovasc Med, Cambridge CB2 2QQ, England

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 05期

关键词：

atherosclerosis; immune system; vascular biology; cytokines; inflammation; COLONY-STIMULATING FACTOR; APOPTOSIS-INDUCING LIGAND; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; DEFICIENCY REDUCES ATHEROSCLEROSIS; RECEPTOR FAMILY-MEMBER; FATTY-STREAK FORMATION; SMOOTH-MUSCLE-CELLS; INTERFERON-GAMMA; IFN-GAMMA;

D O I：

10.1161/ATVBAHA.110.207415

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immune responses. Inflammation controls the development and the destabilization of arterial plaque. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis have provided evidence for a dual role of cytokines: proinflammatory and T helper-1-related cytokines promote the development and progression of the disease, whereas antiinflammatory and regulatory T cell-related cytokines exert clear antiatherogenic activities. This review focuses on recent advances regarding the role of cytokines, with the exception of chemokines, in the development, progression, and complications of atherosclerosis. (Arterioscler Thromb Vasc Biol. 2011;31:969-979.)

引用

页码：969 / 979

页数：11

共 138 条

[1] Natural regulatory T cells control the development of atherosclerosis in mice [J].