Embryonic origin of the adult hematopoietic system: advances and questions

被引：296

作者：

Medvinsky, Alexander ^{[1
]}

Rybtsov, Stanislav ^{[1
]}

Taoudi, Samir ^{[2
]}

机构：

[1] Univ Edinburgh, Inst Stem Cell Res, MRC Ctr Regenerat Med, Edinburgh EH9 3JQ, Midlothian, Scotland

[2] Walter & Eliza Hall Inst Med Res, Div Mol Med, Parkville, Vic 3052, Australia

来源：

DEVELOPMENT | 2011年 / 138卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

AGM region; Yolk sac; Placenta; dHSC; Pre-dHSC; STEM-CELL EMERGENCE; MURINE YOLK-SAC; GONAD-MESONEPHROS REGION; MOUSE EMBRYO; ENDOTHELIAL-CELLS; DEFINITIVE HEMATOPOIESIS; PROGENITOR CELLS; FETAL LIVER; DORSAL AORTA; IN-VIVO;

D O I：

10.1242/dev.040998

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

引用

页码：1017 / 1031

页数：15

共 153 条

[1] Biomechanical forces promote embryonic haematopoiesis [J].

Adamo, Luigi ;

Naveiras, Olaia ;

Wenzel, Pamela L. ;

McKinney-Freeman, Shannon ;

Mack, Peter J. ;

Gracia-Sancho, Jorge ;

Suchy-Dicey, Astrid ;

Yoshimoto, Momoko ;

Lensch, M. William ;

Yoder, Mervin C. ;

Garcia-Cardena, Guillermo ;

Daley, George Q. .

NATURE, 2009, 459 (7250) :1131-U120

[2] Mouse placenta is a major hematopoietic organ [J].

Alvarez-Silva, M ;

Belo-Diabangouaya, P ;

Salaün, J ;

Dieterlen-Lièvre, F .

DEVELOPMENT, 2003, 130 (22) :5437-5444

[3] α4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo [J].

Arroyo, AG ;

Yang, JT ;

Rayburn, H ;

Hynes, RO .

IMMUNITY, 1999, 11 (05) :555-566

[4] Differential requirements for alpha 4 integrins during fetal and adult hematopoiesis [J].

Arroyo, AG ;

Yang, JT ;

Rayburn, H ;

Hynes, RO .

CELL, 1996, 85 (07) :997-1008

[5] The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo [J].

Azcoitia, V ;

Aracil, M ;

Martínez-A, C ;

Torres, M .

DEVELOPMENTAL BIOLOGY, 2005, 280 (02) :307-320

[6] CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis [J].

Bertrand, Julien Y. ;

Kim, Albert D. ;

Teng, Shutian ;

Traver, David .

DEVELOPMENT, 2008, 135 (10) :1853-1862

[7] Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo [J].

Bertrand, Julien Y. ;

Cisson, Jennifer L. ;

Stachura, David L. ;

Traver, David .

BLOOD, 2010, 115 (14) :2777-2783

[8] Haematopoietic stem cells derive directly from aortic endothelium during development [J].

Bertrand, Julien Y. ;

Chi, Neil C. ;

Santoso, Buyung ;

Teng, Shutian ;

Stainier, Didier Y. R. ;

Traver, David .

NATURE, 2010, 464 (7285) :108-U120

[9] Hematopoietic cell development in the zebrafish embryo [J].

Bertrand, Julien Y. ;

Traver, David .

CURRENT OPINION IN HEMATOLOGY, 2009, 16 (04) :243-248

[10] Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin [J].

Bertrand, JY ;

Giroux, S ;

Golub, R ;

Klaine, M ;

Jalil, A ;

Boucontet, L ;

Godin, I ;

Cumano, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (01) :134-139

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