The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

被引：55

作者：

Brouwer, R ^{[1
]}

Pruijn, GJM ^{[1
]}

van Venrooij, WJ ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Biochem, NL-6500 HB Nijmegen, Netherlands

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 02期

关键词：

autoantibodies; autoantigens; exoribonucleases; exosome; PM/Scl complex;

D O I：

10.1186/ar147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3'-->5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.

引用

页码：102 / 106

页数：5

共 51 条

[11] Identification of a regulated pathway for nuclear pre-mRNA turnover [J].

Bousquet-Antonelli, C ;

Presutti, C ;

Tollervey, D .

CELL, 2000, 102 (06) :765-775

[12] Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3′ end formation [J].

Briggs, MW ;

Burkard, KTD ;

Butler, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) :13255-13263

[13]

BROUWER R, 2001, IN PRESS J BIOL CHEM

[14]

BROUWER R, 2001, IN PRESS ANN RHEUM D

[15] A nuclear 3′-5′ exonuclease involved in mRNA degradation interacts with poly(A) polymerase and the hnRNA protein Npl3p [J].

Burkard, KTD ;

Butler, JS .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (02) :604-616

[16] To be or not to be in the nucleolus [J].

Carmo-Fonseca, M ;

Mendes-Soares, L ;

Campos, I .

NATURE CELL BIOLOGY, 2000, 2 (06) :E107-E112

[17]

GE O, 1992, J CLIN INVEST, V90, P559

[18] ANALYSIS OF THE SPECIFICITY OF ANTI-PM-SCL AUTOANTIBODIES [J].

GE, Q ;

WU, YJ ;

TRIEU, EP ;

TARGOFF, IN .

ARTHRITIS AND RHEUMATISM, 1994, 37 (10) :1445-1452

[19]

GELPI C, 1990, CLIN EXP IMMUNOL, V81, P59

[20] IMMUNOGENETIC ASSOCIATIONS OF SCLERODERMA-RELATED ANTINUCLEAR ANTIBODIES [J].

GENTH, E ;

MIERAU, R ;

GENETZKY, P ;

VONMUHLEN, CA ;

KAUFMANN, S ;

VONWILMOWSKY, H ;

MEURER, M ;

KRIEG, T ;

POLLMANN, HJ ;

HARTL, PW .

ARTHRITIS AND RHEUMATISM, 1990, 33 (05) :657-665

← 1 2 3 4 5 6 →