The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

被引：55

作者：

Brouwer, R ^{[1
]}

Pruijn, GJM ^{[1
]}

van Venrooij, WJ ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Biochem, NL-6500 HB Nijmegen, Netherlands

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 02期

关键词：

autoantibodies; autoantigens; exoribonucleases; exosome; PM/Scl complex;

D O I：

10.1186/ar147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3'-->5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.

引用

页码：102 / 106

页数：5

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