Effects of moderate exercise and oat β-glucan on innate immune function and susceptibility to respiratory infection

被引:71
作者
Davis, JM
Murphy, EA
Brown, AS
Carmichael, MD
Ghaffar, A
Mayer, EP
机构
[1] Univ S Carolina, Arnold Sch Publ Hlth, Dept Exercise Sci, Columbia, SC 29208 USA
[2] Univ S Carolina, Sch Med, Dept Pathol & Microbiol, Columbia, SC 29208 USA
关键词
macrophage; natural killer cell; viral infection; morbidity; mortality;
D O I
10.1152/ajpregu.00304.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Both moderate exercise and the soluble oat fiber beta-glucan can increase immune function and decrease risk of infection, but no information exists on their possible combined effects. This study tested the effects of moderate exercise and oat beta-glucan on respiratory infection, macrophage antiviral resistance, and natural killer (NK) cell cytotoxicity. Mice were assigned to four groups: exercise and water, exercise and oat beta-glucan, control water, or control oat beta-glucan. Oat beta-glucan was fed in the drinking water for 10 days before intranasal inoculation of herpes simplex virus type 1 (HSV-1) or euthanasia. Exercise consisted of treadmill running (1 h/day) for 6 days. Macrophage resistance to HSV-1 was increased with both exercise and oat beta-glucan, whereas NK cell cytotoxicity was only increased with exercise. Exercise was also associated with a 45 and 38% decrease in morbidity and mortality, respectively. Mortality was also decreased with oat beta-glucan, but this effect did not reach statistical significance. No additive effects of exercise and oat beta-glucan were found. These data confirm a positive effect of both moderate exercise and oat beta-glucan on immune function, but only moderate exercise was associated with a significant reduction in the risk of upper respiratory tract infection in this model.
引用
收藏
页码:R366 / R372
页数:7
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