An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder

被引:32
作者
Dickey, CC
McCarley, RW
Voglmaier, MM
Niznikiewicz, MA
Seidman, LJ
Demeo, S
Frumin, M
Shenton, ME
机构
[1] Harvard Univ, Sch Med, VA Boston Healthcare Syst, Dept Psychiat,Clin Neurosci Div,Lab Neurosci, Brockton, MA 02401 USA
[2] Harvard Univ, Sch Med, Dept Radiol, Surg Planning Lab,MRI Div, Boston, MA USA
[3] Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA USA
[4] Massachusetts Mental Hlth Ctr, Boston, MA USA
关键词
D O I
10.1176/appi.ajp.160.12.2198
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: An abnormal superior temporal gyrus has figured prominently in schizophrenia research, and left superior temporal gyrus volume has been shown to be smaller in male subjects with schizotypal personality disorder. This is the first structural magnetic resonance imaging study to examine a group of female subjects with schizotypal personality disorder. Method: The superior temporal gyrus was drawn on coronal images acquired from female subjects recruited from the community (schizotypal personality disorder group: N=21, comparison group: N=29). Results: There were no gray matter volume differences in the left or right superior temporal gyrus between the subjects with schizotypal personality disorder and the comparison subjects. Within the schizotypal personality disorder group, however, there was an interaction be-tween hemisphere and family history of mental illness. Moreover, subjects with schizotypal personality disorder did demonstrate formal thought disorder and a negative correlation between left superior temporal gyrus volume and odd speech. Conclusions: This study of female subjects with schizotypal personality disorder showed no superior temporal gyrus volume differences, but preliminary findings indicate that among female subjects with schizotypal personality disorder, there is a left-right difference in those who have a family history of mental illness relative to those who do not. These data also suggest an association between abnormal speech and left superior temporal gyrus volume, a finding similar to that found in schizophrenia. Results from this study thus clearly reinforce the importance of studying female subjects separately.
引用
收藏
页码:2198 / 2201
页数:4
相关论文
共 15 条
[1]  
Bryant NL, 1999, AM J PSYCHIAT, V156, P603
[2]   Reduced left Heschl's gyrus volume in schizotypal personality disorder [J].
Dickey, CC ;
Shenton, ME ;
Fraone, S ;
Niznikiewicz, MA ;
Voglmaier, MM ;
Seidman, LJ ;
Hirayasu, Y ;
Kwon, JS ;
Fischer, IA ;
Anderson, J ;
Frumin, M ;
McCarley, RW .
BIOLOGICAL PSYCHIATRY, 2000, 47 (08) :13S-14S
[3]   Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter [J].
Dickey, CC ;
McCarley, RW ;
Voglmaier, MM ;
Niznikiewicz, MA ;
Seidman, LJ ;
Hirayasu, Y ;
Fischer, I ;
Teh, EK ;
Van Rhoads, R ;
Jakab, M ;
Kikinis, R ;
Jolesz, FA ;
Shenton, ME .
BIOLOGICAL PSYCHIATRY, 1999, 45 (11) :1393-1402
[4]  
Dickey CC, 2002, HARVARD REV PSYCHIAT, V10, P1
[5]   Large CSF volume not attributable to ventricular volume in schizotypal personality disorder [J].
Dickey, CC ;
Shenton, ME ;
Hirayasu, Y ;
Fischer, I ;
Voglmaier, MM ;
Niznikiewicz, MA ;
Seidman, LJ ;
Fraone, S ;
McCarley, RW .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (01) :48-54
[6]   Temporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophrenia [J].
Downhill, JE ;
Buchsbaum, MS ;
Hazlett, EA ;
Barth, S ;
Roitman, SL ;
Nunn, M ;
Lekarev, O ;
Wei, TC ;
Shihabuddin, L ;
Mitropoulou, V ;
Silverman, J ;
Siever, LJ .
SCHIZOPHRENIA RESEARCH, 2001, 48 (2-3) :187-199
[7]  
FLAUM M, 1995, AM J PSYCHIAT, V152, P704
[8]   Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging [J].
Goldstein, JM ;
Seidman, LJ ;
Horton, NJ ;
Makris, N ;
Kennedy, DN ;
Caviness, VS ;
Faraone, SV ;
Tsuang, MT .
CEREBRAL CORTEX, 2001, 11 (06) :490-497
[9]   Temporolimbic volume reductions in schizophrenia [J].
Gur, RE ;
Turetsky, BI ;
Cowell, PE ;
Finkelman, C ;
Maany, V ;
Grossman, RI ;
Arnold, SE ;
Bilker, WB ;
Gur, RC .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (08) :769-775
[10]  
Johnston M.H., 1979, ASSESSING SCHIZOPHRE