Appetite regulation: Shedding new light on obesity

被引:7
作者
Billington, CJ
Levine, AS
机构
[1] Minnesota Obesity Center, Minneapolis Vet.' Aff. Med. Center, Minneapolis
关键词
D O I
10.1016/S0960-9822(02)00626-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Several genes involved in the regulation of appetite and energy metabolism have been cloned and characterized recently. Each seems to form part of the complex regulatory network, centred in the hypothalamus, that is responsible for striking a balance between food intake and energy expenditure.
引用
收藏
页码:920 / 923
页数:4
相关论文
共 29 条
[1]
Billington C J, 1992, Curr Opin Neurobiol, V2, P847, DOI 10.1016/0959-4388(92)90144-A
[2]
NEUROPEPTIDE-Y IN HYPOTHALAMIC PARAVENTRICULAR NUCLEUS - A CENTER COORDINATING ENERGY-METABOLISM [J].
BILLINGTON, CJ ;
BRIGGS, JE ;
HARKER, S ;
GRACE, M ;
LEVINE, AS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (06) :R1765-R1770
[3]
RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].
CAMPFIELD, LA ;
SMITH, FJ ;
GUISEZ, Y ;
DEVOS, R ;
BURN, P .
SCIENCE, 1995, 269 (5223) :546-549
[4]
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin [J].
Chehab, FE ;
Lim, ME ;
Lu, RH .
NATURE GENETICS, 1996, 12 (03) :318-320
[5]
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice [J].
Chen, H ;
Charlat, O ;
Tartaglia, LA ;
Woolf, EA ;
Weng, X ;
Ellis, SJ ;
Lakey, ND ;
Culpepper, J ;
Moore, KJ ;
Breitbart, RE ;
Duyk, GM ;
Tepper, RI ;
Morgenstern, JP .
CELL, 1996, 84 (03) :491-495
[6]
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [J].
Chua, SC ;
Chung, WK ;
WuPeng, XS ;
Zhang, YY ;
Liu, SM ;
Tartaglia, L ;
Leibel, RL .
SCIENCE, 1996, 271 (5251) :994-996
[7]
COLEMAN DL, 1969, AM J PHYSIOL, V217, P1298
[8]
EFFECTS OF PARABIOSIS OF OBESE WITH DIABETES AND NORMAL MICE [J].
COLEMAN, DL .
DIABETOLOGIA, 1973, 9 (04) :294-298
[9]
Role of leptin in fat regulation [J].
Collins, S ;
Kuhn, CM ;
Petro, AE ;
Swick, AG ;
Chrunyk, BA ;
Surwit, RS .
NATURE, 1996, 380 (6576) :677-677
[10]
Serum immunoreactive leptin concentrations in normal-weight and obese humans [J].
Considine, RV ;
Sinha, MK ;
Heiman, ML ;
Kriauciunas, A ;
Stephens, TW ;
Nyce, MR ;
Ohannesian, JP ;
Marco, CC ;
McKee, LJ ;
Bauer, TL ;
Caro, JF .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :292-295