Wave propagation in cardiac tissue and effects of intracellular calcium dynamics (computer simulation study)

被引：22

作者：

Chudin, E

Garfinkel, A

Weiss, J

Karplus, W

Kogan, B

机构：

[1] Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Cardiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90095 USA

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 1998年 / 69卷 / 2-3期

关键词：

D O I：

10.1016/S0079-6107(98)00009-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computer simulation using Luo-Rudy I1 model of ventricular myocyte showed that intracellular calcium dynamics become irregular in case of high rate stimulation. This causes the transition from stationary to nonstationary spiral wave and its breakup in 2D model of cardiac tissue. Obtained results suggest how ventricular fibrillation may occur due to the abnormalities of intracellular calcium dynamics. The short review of existing cardiac cell models with calcium dynamics is presented. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：225 / 236

页数：12

共 16 条

[1] A MODEL OF CARDIAC ELECTRICAL-ACTIVITY INCORPORATING IONIC PUMPS AND CONCENTRATION CHANGES
DIFRANCESCO, D
NOBLE, D
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1985, 307 (1133) : 353 - 398
[2] A MODEL OF THE SINGLE ATRIAL CELL - RELATION BETWEEN CALCIUM CURRENT AND CALCIUM RELEASE
EARM, YE
NOBLE, D
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1990, 240 (1297): : 83 - 96
[3] TIME AND CALCIUM DEPENDENCE OF ACTIVATION AND INACTIVATION OF CALCIUM-INDUCED RELEASE OF CALCIUM FROM THE SARCOPLASMIC-RETICULUM OF A SKINNED CANINE CARDIAC PURKINJE-CELL
FABIATO, A
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1985, 85 (02) : 247 - 289
[4] GRAY RA, 1995, SCIENCE, V270, P1222, DOI 10.1126/science.270.5239.1222
[5] EXCITATION CONTRACTION COUPLING AND EXTRACELLULAR CALCIUM TRANSIENTS IN RABBIT ATRIUM - RECONSTRUCTION OF BASIC CELLULAR MECHANISMS
HILGEMANN, DW
NOBLE, D
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1987, 230 (1259): : 163 - 205
[6] 2 STRUCTURALLY DISTINCT CALCIUM STORAGE SITES IN RAT CARDIAC SARCOPLASMIC-RETICULUM - AN ELECTRON-MICROPROBE ANALYSIS STUDY
JORGENSEN, AO
BRODERICK, R
SOMLYO, AP
SOMLYO, AV
[J]. CIRCULATION RESEARCH, 1988, 63 (06) : 1060 - 1069
[7] SPIRAL BREAKUP IN MODEL-EQUATIONS OF ACTION-POTENTIAL PROPAGATION IN CARDIAC TISSUE
KARMA, A
[J]. PHYSICAL REVIEW LETTERS, 1993, 71 (07) : 1103 - 1106
[8] Electrical alternans and spiral wave breakup in cardiac tissue
Karma, Alain
[J]. CHAOS, 1994, 4 (03) : 461 - 472
[9] A model of the action potential and underlying membrane currents in a rabbit atrial cell
Lindblad, DS
Murphey, CR
Clark, JW
Giles, WR
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 271 (04): : H1666 - H1696
[10] A hierarchical concept of cellular and subcellular Ca2+-signalling
Lipp, P
Niggli, E
[J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1996, 65 (03) : 265 - 296

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