Biochemistry of frog ribonucleases

被引：69

作者：

Irie, M

Nitta, K

Nonaka, T

机构：

[1] Hoshi Coll Pharm, Dept Microbiol, Shinagawa Ku, Tokyo 142, Japan

[2] Tohoku Coll Pharmaceut Sci, Canc Res Inst, Sendai, Miyagi 981, Japan

[3] Nagaoka Univ Technol, Nagaoka, Niigata 94021, Japan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1998年 / 54卷 / 08期

关键词：

frog RNase; lectin activity; antitumour activity; pyrimidine base-specific RNase; amphibian RNase;

D O I：

10.1007/s000180050206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Frogs have unique pyrimidine base-specific RNases, with structures similar to those of turtle, iguana and chicken RNases. Among the four frog RNases discussed here, three from Rana pipiens, R. catesbeiana and R. japonica oocyte cells show antitumour activity, and the latter two show lectin activity towards sialic acid-rich glycoproteins. In this review, (i) we compare their unique primary structures with respect to the locations of their disulphide bridges, three-dimensional structure, base specificity and heat stability as compared with RNase A, and (ii) we summarize current knowledge about the mode of action of lectin and the antitumour activities of the three frog RNases.

引用

页码：775 / 784

页数：10

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