Rhomboid-like proteins in apicomplexa: phylogeny and nomenclature

被引：80

作者：

Dowse, TJ ^{[1
]}

Soldati, D ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Sci Biol, London SW7 2AZ, England

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.pt.2005.04.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Rhomboids form a family of polytopic intramembrane serine proteases. In Toxoplasma gondii, an essential activity called microneme protein protease 1 (MPP1) cleaves secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene. In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses.

引用

页码：254 / 258

页数：5

共 25 条

[1] Complete genome sequence of the apicomplexan, Cryptosporidium parvum [J].

Abrahamsen, MS ;

Templeton, TJ ;

Enomoto, S ;

Abrahante, JE ;

Zhu, G ;

Lancto, CA ;

Deng, MQ ;

Liu, C ;

Widmer, G ;

Tzipori, S ;

Buck, GA ;

Xu, P ;

Bankier, AT ;

Dear, PH ;

Konfortov, BA ;

Spriggs, HF ;

Iyer, L ;

Anantharaman, V ;

Aravind, L ;

Kapur, V .

SCIENCE, 2004, 304 (5669) :441-445

[2] The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum [J].

Bozdech, Z ;

Llinás, M ;

Pulliam, BL ;

Wong, ED ;

Zhu, JC ;

DeRisi, JL .

PLOS BIOLOGY, 2003, 1 (01) :85-100

[3] A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma [J].

Brossier, F ;

Jewett, TJ ;

Sibley, LD ;

Urban, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) :4146-4151

[4] C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells [J].

Brossier, F ;

Jewettt, TJ ;

Lovett, JL ;

Sibley, LD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) :6229-6234

[5] Secretion of micronemal proteins is associated with toxoplasma invasion of host cells [J].

Carruthers, VB ;

Giddings, OK ;

Sibley, LD .

CELLULAR MICROBIOLOGY, 1999, 1 (03) :225-235

[6] A new release on life: emerging concepts in proteolysis and parasite invasion [J].

Carruthers, VB ;

Blackman, MJ .

MOLECULAR MICROBIOLOGY, 2005, 55 (06) :1617-1630

[7] The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases [J].

Carruthers, VB ;

Sherman, GD ;

Sibley, LD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14346-14353

[8] Serine protease inhibitors block invasion of host cells by Toxoplasma gondii [J].

Conseil, V ;

Soête, M ;

Dubremetz, JF .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1358-1361

[9] Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis [J].

Dowse, T ;

Soldati, D .

CURRENT OPINION IN MICROBIOLOGY, 2004, 7 (04) :388-396

[10]

DOWSE T, 2005, IN PRESS INT J PARAS

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