Systems biology of vaccination for seasonal influenza in humans

被引：633

作者：

Nakaya, Helder I. ^{[1
,2
]}

Wrammert, Jens ^{[1
,3
]}

Lee, Eva K. ^{[4
]}

Racioppi, Luigi ^{[5
,6
]}

Marie-Kunze, Stephanie ^{[1
,2
]}

Haining, W. Nicholas ^{[7
]}

Means, Anthony R. ^{[6
]}

Kasturi, Sudhir P. ^{[1
,2
]}

Khan, Nooruddin ^{[1
,2
]}

Li, Gui-Mei ^{[1
,3
]}

McCausland, Megan ^{[1
,3
]}

Kanchan, Vibhu ^{[1
,3
]}

Kokko, Kenneth E. ^{[8
]}

Li, Shuzhao ^{[1
,2
]}

Elbein, Rivka ^{[9
]}

Mehta, Aneesh K. ^{[9
]}

Aderem, Alan ^{[10
]}

Subbarao, Kanta ^{[11
]}

Ahmed, Rafi ^{[1
,3
]}

Pulendran, Bali ^{[1
,2
,12
]}

机构：

[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[4] Georgia Inst Technol, Sch Ind & Syst Engn, Ctr Operat Res Med & Healthcare, Atlanta, GA 30332 USA

[5] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC USA

[6] Univ Naples Federico II, Dept Cellular & Mol Biol & Pathol, Naples, Italy

[7] Dana Farber Canc Inst, Boston, MA 02115 USA

[8] Emory Univ, Sch Med, Dept Med, Div Nephrol, Atlanta, GA USA

[9] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[10] Inst Syst Biol, Seattle, WA USA

[11] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[12] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 08期

基金：

美国国家科学基金会; 比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

YELLOW-FEVER VACCINE; PROTEIN-KINASE-IV; PLASMA-CELL DIFFERENTIATION; IMMUNE-RESPONSES; TRANSCRIPTION FACTOR; ANTIBODY-RESPONSES; CUTTING EDGE; T-CELLS; LIVE; CHILDREN;

D O I：

10.1038/ni.2067

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines.

引用

页码：786 / U149

页数：11

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