The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic Injury

被引:76
作者
Schröder, UH
Breder, J
Sabelhaus, CF
Reymann, KG
机构
[1] Leibniz Inst Neurobiol, Project Grp Neuropharmacol, D-39008 Magdeburg, Germany
[2] Res Inst Appl Neurosci GmbH, D-39120 Magdeburg, Germany
关键词
hypoxia; hypoglycemia; inhibitor; Na+/Ca2+ exchanger; neuroprotection; rat hippocampal slice; KB-R7943;
D O I
10.1016/S0028-3908(98)00198-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:319 / 321
页数:3
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