hypoxia;
hypoglycemia;
inhibitor;
Na+/Ca2+ exchanger;
neuroprotection;
rat hippocampal slice;
KB-R7943;
D O I:
10.1016/S0028-3908(98)00198-1
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons. (C) 1999 Elsevier Science Ltd. All rights reserved.