The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic Injury

被引：76

作者：

Schröder, UH

Breder, J

Sabelhaus, CF

Reymann, KG

机构：

[1] Leibniz Inst Neurobiol, Project Grp Neuropharmacol, D-39008 Magdeburg, Germany

[2] Res Inst Appl Neurosci GmbH, D-39120 Magdeburg, Germany

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 02期

关键词：

hypoxia; hypoglycemia; inhibitor; Na+/Ca2+ exchanger; neuroprotection; rat hippocampal slice; KB-R7943;

D O I：

10.1016/S0028-3908(98)00198-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：319 / 321

页数：3

共 7 条

[1]

ANDERSEN P, 1971, EXP BRAIN RES, V13, P208

[2] INHIBITION OF NA+/CA2+ EXCHANGE ENHANCES DELAYED NEURONAL DEATH ELICITED BY GLUTAMATE IN CEREBELLAR GRANULE CELL-CULTURES [J].