Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time of flight magnetic resonance angiography of the body

被引:61
作者
Bourne, MW [1 ]
Margerun, L [1 ]
Hylton, N [1 ]
Campion, B [1 ]
Lai, JJ [1 ]
Derugin, N [1 ]
Higgins, CB [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT RADIOL,SAN FRANCISCO,CA 94143
来源
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1996年 / 6卷 / 02期
关键词
contrast media; blood pool; intravascular; MR angiography; MR contrast media;
D O I
10.1002/jmri.1880060209
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The aims of this preliminary study were to establish the efficacy and minimum effective dose of TG(5)(FdDO3A)(52) gadolinium dendrimer for contrast-enhanced, three-dimensional (3D) time of flight (TOF) magnetic resonance angiography (MRA) of the body, In a dose ranging study in eight rabbits (Group A), each of two animals received 0.03; 0.02; 0.01; or 0.005 mmol/kg of the agent for 3D-TOF MRA of the pelvic circulation in the axial and coronal planes. An additional nine animals (Group B) received a dose of 0.02 mmol/kg for 3D-TOF MRA of the mediastinum, abdomen or of the lower limbs, Quantitative and qualitative analyses of the Images from Group A demonstrated a dose-related reduction in saturation effects and improved visualization of vascular structures, with maximal augmentation of the contrast-to-noise ratio (CNR) at 0.03 mmol/kg, The dose of 0.02 mmol/kg was found to be the minimal effective dose at the three vascular regions.
引用
收藏
页码:305 / 310
页数:6
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