Mesial temporal lobe epilepsy: A pathological replay of developmental mechanisms?

被引：45

作者：

Cohen, I ^{[1
]}

Navarro, V ^{[1
]}

Le Duigou, C ^{[1
]}

Miles, R ^{[1
]}

机构：

[1] Univ Paris 06, INSERM, EMI 0224, CHUPS, F-75013 Paris, France

来源：

BIOLOGY OF THE CELL | 2003年 / 95卷 / 06期

关键词：

epilepsy; development; cell death; synapse; excitability;

D O I：

10.1016/S0248-4900(03)00081-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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页码：329 / 333

页数：5

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[1] Induction of neonatal sodium channel II and III α-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus [J].

Aronica, E ;

Yankaya, B ;

Troost, D ;

van Vliet, EA ;

da Silva, FHL ;

Gorter, JA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (06) :1261-1266

[2] 4-AMINOPYRIDINE INDUCES A LONG-LASTING DEPOLARIZING GABA-ERGIC POTENTIAL IN HUMAN NEOCORTICAL AND HIPPOCAMPAL-NEURONS MAINTAINED INVITRO [J].

AVOLI, M ;

PERREAULT, P ;

OLIVIER, A ;

VILLEMURE, JG .

NEUROSCIENCE LETTERS, 1988, 94 (03) :327-332

[3] Control of synaptic strength by glial TNFα [J].

Beattie, EC ;

Stellwagen, D ;

Morishita, W ;

Bresnahan, JC ;

Ha, BK ;

Von Zastrow, M ;

Beattie, MS ;

Malenka, RC .

SCIENCE, 2002, 295 (5563) :2282-2285

[4]

Bechmann I, 2000, ANN NY ACAD SCI, V911, P192

[5] LIMBIC SEIZURE AND BRAIN-DAMAGE PRODUCED BY KAINIC ACID - MECHANISMS AND RELEVANCE TO HUMAN TEMPORAL-LOBE EPILEPSY [J].

BENARI, Y .

NEUROSCIENCE, 1985, 14 (02) :375-403

[6] GIANT SYNAPTIC POTENTIALS IN IMMATURE RAT CA3 HIPPOCAMPAL-NEURONS [J].

BENARI, Y ;

CHERUBINI, E ;

CORRADETTI, R ;

GAIARSA, JL .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 416 :303-325

[7]

Carmichael ST, 2002, J NEUROSCI, V22, P6062

[8] On the origin of interictal activity in human temporal lobe epilepsy in vitro [J].

Cohen, I ;

Navarro, V ;

Clemenceau, S ;

Baulac, M ;

Miles, R .

SCIENCE, 2002, 298 (5597) :1418-1421

[9] Ion channel genes and human neurological disease: Recent progress, prospects, and challenges [J].

Cooper, EC ;

Jan, LY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :4759-4766

[10] Recovery recapitulates ontogeny [J].

Cramer, SC ;

Chopp, M .

TRENDS IN NEUROSCIENCES, 2000, 23 (06) :265-271

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