Open systems: panoramic views of gene expression

被引：59

作者：

Green, CD

Simons, JF

Taillon, BE

Lewin, DA

机构：

[1] CuraGen Corp, Dept Gene Discovery, New Haven, CT 06511 USA

[2] CuraGen Corp, Dept Engn & Technol Dev, New Haven, CT 06511 USA

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 2001年 / 250卷 / 1-2期

关键词：

differential gene expression; GeneCalling; gene chip; open systems; quantitative expression analysis; WECHE;

D O I：

10.1016/S0022-1759(01)00306-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Since their development in the early 1990s, differential gene expression (DGE) technologies have been applied to a multitude of biological challenges, both for the purpose of basic biological research and as a valuable tool for the discovery and development of pharmaceuticals. In this review we survey a class of DGE technologies collectively referred to as 'open' architecture systems. These technologies are distinct from the 'closed' DGE technologies (quantitative PCR, chip technologies), in that no pre-existing biological or sequence information is necessary and they are applicable to any species. Examples of open systems include GeneCalling (R):, SAGE, TOGA, READS (TM) and their progenitor DGE technologies, differential display and cDNA representational difference analysis. We review these technologies and summarize a specific application using GeneCalling for novel gene discovery. Additionally, the significance of data management and experimental design in this new age of expression analysis is discussed. (C) 2001 Elsevier Science BN. All rights reserved.

引用

页码：67 / 79

页数：13

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