Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment

被引：25

作者：

Castello, Giuseppe ^{[1
]}

Costantini, Susan ^{[1
]}

Scala, Stefania ^{[2
]}

机构：

[1] CROM, Mercogliano, AV, Italy

[2] G Pascale Fdn, Natl Canc Inst Naples, Naples, Italy

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2010年 / 8卷

关键词：

HEPATITIS-C VIRUS; ADAPTIVE IMMUNE-RESPONSES; GROWTH-FACTOR-BETA; 2ND PRIMARY TUMORS; CD8(+) T-CELLS; OXIDATIVE STRESS; RAT-LIVER; LIPID-PEROXIDATION; VIRAL-HEPATITIS; DENDRITIC CELLS;

D O I：

10.1186/1479-5876-8-109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemo-prevention targeting the microenvironment.

引用

页数：11

共 109 条

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OXIDATIVE DAMAGE TO DNA - RELATION TO SPECIES METABOLIC-RATE AND LIFE-SPAN [J].