DNA-Carbon Dots Function as Fluorescent Vehicles for Drug Delivery

被引：236

作者：

Ding, Han ^{[1
,2
]}

Du, Feiyue ^{[1
,2
,3
]}

Liu, Pengchang ^{[1
,2
,3
]}

Chen, Zhijun ^{[1
,2
,3
]}

Shen, Jiacong ^{[1
,2
]}

机构：

[1] Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

[2] Jilin Univ, Int Joint Res Lab Nanomicro Architecture Chem, Changchun 130012, Peoples R China

[3] Jilin Univ, Inst Theoret Chem, Changchun 130012, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 12期

基金：

中国国家自然科学基金;

关键词：

DNA-carbon dots; new bond formation; fluorescent vehicle; drug delivery; ONE-STEP SYNTHESIS; POT GREEN SYNTHESIS; QUANTUM DOTS; CONTROLLABLE SYNTHESIS; SENSITIVE DETECTION; AMINO-ACIDS; NITROGEN; NANODOTS; NANOPARTICLES; XPS;

D O I：

10.1021/acsami.5b00628

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Carbon dots (CDs) are a new representative in the carbon-based material family, attracting tremendous interest in a large variety of fields, including biomedicine. In this report, we described a facile and green system for synthesizing DNA-CDs using genomic DNA isolated from Escherichia coli. DNA-CDs can be purified using a simple column centrifugation-based system. During DNA-CD synthesis, ribose was collapsed, accompanied by the release of nitrogen, and several new bonds (C-OH, N-O, and N-P) were formed, while the other covalent bonds of DNA were largely maintained. The presence of abundant chemical groups, such as amino or hydroxyl groups on DNA-CDs, may facilitate their future functionalization. These highly biocompatible DNA-CDs can serve as a new type of fluorescent vehicle for cell imaging and drug delivery studies. Our research may hasten the development of CDs for prominent future biomedical applications.

引用

页码：6889 / 6897

页数：9

共 66 条

[1]

P2O5 Assisted Green Synthesis of Multicolor Fluorescent Water Soluble Carbon Dots [J].