Using a temporary silicon connection in stereoselective allylation with allylsilanes: Application to the synthesis of stereodefined 1,2,4-triols

被引：23

作者：

Beignet, J ^{[1
]}

Cox, LR ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 22期

关键词：

D O I：

10.1021/ol035762o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of aldehyde 6 with TMSOTf, in the presence of a Bronsted acid scavenger, effects an intramolecular allylation to provide the oxasilacycle 7 as the major diastereoisomer. Tamao oxidation of the C-Si bond in 7 affords the corresponding 1,2,4-triol 9.

引用

页码：4231 / 4234

页数：4

共 27 条

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