Antiallergic agents from natural sources.: 3.: Structures and inhibitory effects on nitric oxide production and histamine release of five novel polyacetylene glucosides from Bidens parviflora WILLD.

被引：55

作者：

Wang, NL

Yao, XS

Ishii, R

Kitanaka, S

机构：

[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110015, Peoples R China

[2] Saitama Inst Publ Hlth, Urawa, Saitama 3380824, Japan

[3] Nihon Univ, Coll Pharm, Chiba 2748555, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 08期

关键词：

Bidens parviflora WILLD; polyacetylene glucoside; Mosher method; mast cell; macrophage; histamine release inhibitor; NO production inhibitor;

D O I：

10.1248/cpb.49.938

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Five new polyacetylene glucosides, bidensyneosides A(1), A(2), B, C (1-4), and 3-deoxybidensyncoside B (5). have been isolated from the air-dried whole plant of Bidens parviflora WH.I.D. The structures were identified based on spectroscopic analysis, physicochemical properties, and application of the modified Mosher method to be 3(R),8(E)-8-decene-4,6-diyne-1,3-diol 1-O-beta -D-glucopyranoside (1), deca-3(R),S(Z) 8-decene-4,6-diyne-1,3-diol 1-O-beta -D-glucopyranoside (2), 3(R)-deca-4,6,8-triyne-1,3-diol 1-O-beta -D-glucopyranoside (3), 3(R),8(E)-8-decene-4,6-diyne-1,3,10-triol 1-O-beta -glucopyranoside (4), and 8(E)-8-decene-4.6-diyne-1,10-diol 1-O-beta -D-glucopyranoside (5), respectively. These compounds inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-gamma activated murine macrophages (RAW264.7) and also inhibited histamine release from rat mast cells stimulated by the antigen-antibody reaction.

引用

页码：938 / 942

页数：5

共 20 条

[1]

THE CELL BIOLOGY OF MACROPHAGE ACTIVATION [J].