Assessing and managing risk when sharing aggregate genetic variant data

被引：42

作者：

Craig, David W. ^{[1
]}

Goor, Robert M. ^{[2
]}

Wang, Zhenyuan ^{[2
]}

Paschall, Justin ^{[2
]}

Ostell, Jim ^{[2
]}

Feolo, Michael ^{[2
]}

Sherry, Stephen T. ^{[2
]}

Manolio, Teri A. ^{[3
]}

机构：

[1] TGen, Res Inst, Translat Genom, Phoenix, AZ 85004 USA

[2] NCBI, Bethesda, MD 20892 USA

[3] NHGRI, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 10期

关键词：

GENOME-WIDE ASSOCIATION; POPULATION; LOCI; REPLICATION; EFFICIENT; PRIVACY; DISEASE;

D O I：

10.1038/nrg3067

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Access to genetic data across studies is an important aspect of identifying new genetic associations through genome-wide association studies (GWASs). Meta-analysis across multiple GWASs with combined cohort sizes of tens of thousands of individuals often uncovers many more genome-wide associated loci than the original individual studies; this emphasizes the importance of tools and mechanisms for data sharing. However, even sharing summary-level data, such as allele frequencies, inherently carries some degree of privacy risk to study participants. Here we discuss mechanisms and resources for sharing data from GWASs, particularly focusing on approaches for assessing and quantifying the privacy risks to participants that result from the sharing of summary-level data.

引用

页码：730 / 736

页数：7

共 43 条

[1] A map of human genome variation from population-scale sequencing [J].

Altshuler, David ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Collins, Francis S. ;

De la Vega, Francisco M. ;

Donnelly, Peter ;

Egholm, Michael ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Knoppers, Bartha M. ;

Lander, Eric S. ;

Lehrach, Hans ;

Mardis, Elaine R. ;

McVean, Gil A. ;

Nickerson, DebbieA. ;

Peltonen, Leena ;

Schafer, Alan J. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Deiros, David ;

Metzker, Mike ;

Muzny, Donna ;

Reid, Jeff ;

Wheeler, David ;

Wang, Jun ;

Li, Jingxiang ;

Jian, Min ;

Li, Guoqing ;

Li, Ruiqiang ;

Liang, Huiqing ;

Tian, Geng ;

Wang, Bo ;

Wang, Jian ;

Wang, Wei ;

Yang, Huanming ;

Zhang, Xiuqing ;

Zheng, Huisong ;

Lander, Eric S. ;

Altshuler, David L. ;

Ambrogio, Lauren ;

Bloom, Toby ;

Cibulskis, Kristian ;

Fennell, Tim J. ;

Gabriel, Stacey B. .

NATURE, 2010, 467 (7319) :1061-1073

[2] Needles in the Haystack: Identifying Individuals Present in Pooled Genomic Data [J].

Braun, Rosemary ;

Rowe, William ;

Schaefer, Carl ;

Zhang, Jinghui ;

Buetow, Kenneth .

PLOS GENETICS, 2009, 5 (10)

[3] Public Access to Genome-Wide Data: Five Views on Balancing Research with Privacy and Protection [J].

Church, George ;

Heeney, Catherine ;

Hawkins, Naomi ;

de Vries, Jantina ;

Boddington, Paula ;

Kaye, Jane ;

Bobrow, Martin ;

Weir, Bruce .

PLOS GENETICS, 2009, 5 (10)

[4] A framework for interpreting genome-wide association studies of psychiatric disorders The Psychiatric GWAS Consortium Steering Committee [J].

Cichon, Sven ;

Craddock, Nick ;

Daly, Mark ;

Faraone, Stephen V. ;

Gejman, Pablo V. ;

Kelsoe, John ;

Lehner, Thomas ;

Levinson, Douglas F. ;

Moran, Audra ;

Sklar, Pamela ;

Sullivan, Patrick F. .

MOLECULAR PSYCHIATRY, 2009, 14 (01) :10-17

[5] On inferring presence of an individual in a mixture: a Bayesian approach [J].

Clayton, David .

BIOSTATISTICS, 2010, 11 (04) :661-673

[6] The Gene, Environment Association Studies Consortium (GENEVA): Maximizing the Knowledge Obtained from GWAS by Collaboration Across Studies of Multiple Conditions [J].

Cornelis, Marilyn C. ;

Agrawal, Arpana ;

Cole, John W. ;

Hansel, Nadia N. ;

Barnes, Kathleen C. ;

Beaty, Terri H. ;

Bennett, Siiri N. ;

Bierut, Laura J. ;

Boerwinkle, Eric ;

Doheny, Kimberly F. ;

Feenstra, Bjarke ;

Feingold, Eleanor ;

Fornage, Myriam ;

Haiman, Christopher A. ;

Harris, Emily L. ;

Hayes, M. Geoffrey ;

Heit, John A. ;

Hu, Frank B. ;

Kang, Jae H. ;

Laurie, Cathy C. ;

Ling, Hua ;

Manolio, Teri A. ;

Marazita, Mary L. ;

Mathias, Rasika A. ;

Mirel, Daniel B. ;

Paschall, Justin ;

Pasquale, Louis R. ;

Pugh, Elizabeth W. ;

Rice, John P. ;

Udren, Jenna ;

van Dam, Rob M. ;

Wang, Xiaojing ;

Wiggs, Janey L. ;

Williams, Kayleen ;

Yu, Kai .

GENETIC EPIDEMIOLOGY, 2010, 34 (04) :364-372

[7] Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis [J].

Elias-Sonnenschein, Lyzel S. ;

Viechtbauer, Wolfgang ;

Ramakers, Inez H. G. B. ;

Verhey, Frans R. J. ;

Visser, Pieter Jelle .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (10) :1149-1156

[8] A second generation human haplotype map of over 3.1 million SNPs [J].

Frazer, Kelly A. ;

Ballinger, Dennis G. ;

Cox, David R. ;

Hinds, David A. ;

Stuve, Laura L. ;

Gibbs, Richard A. ;

Belmont, John W. ;

Boudreau, Andrew ;

Hardenbol, Paul ;

Leal, Suzanne M. ;

Pasternak, Shiran ;

Wheeler, David A. ;

Willis, Thomas D. ;

Yu, Fuli ;

Yang, Huanming ;

Zeng, Changqing ;

Gao, Yang ;

Hu, Haoran ;

Hu, Weitao ;

Li, Chaohua ;

Lin, Wei ;

Liu, Siqi ;

Pan, Hao ;

Tang, Xiaoli ;

Wang, Jian ;

Wang, Wei ;

Yu, Jun ;

Zhang, Bo ;

Zhang, Qingrun ;

Zhao, Hongbin ;

Zhao, Hui ;

Zhou, Jun ;

Gabriel, Stacey B. ;

Barry, Rachel ;

Blumenstiel, Brendan ;

Camargo, Amy ;

Defelice, Matthew ;

Faggart, Maura ;

Goyette, Mary ;

Gupta, Supriya ;

Moore, Jamie ;

Nguyen, Huy ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Roy, Jessica ;

Stahl, Erich ;

Winchester, Ellen ;

Ziaugra, Liuda ;

Altshuler, David ;

Shen, Yan .

NATURE, 2007, 449 (7164) :851-U3

[9] Public Perspectives Regarding Data-Sharing Practices in Genomics Research [J].

Haga, S. B. ;

O'Daniel, J. .

PUBLIC HEALTH GENOMICS, 2011, 14 (06) :319-324

[10] Assessing the Privacy Risks of Data Sharing in Genomics [J].

Heeney, C. ;

Hawkins, N. ;

de Vries, J. ;

Boddington, P. ;

Kaye, J. .

PUBLIC HEALTH GENOMICS, 2011, 14 (01) :17-25

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