Journey of the iodide transporter NIS:: from its molecular identification to its clinical role in cancer

被引：54

作者：

Riedel, C ^{[1
]}

Dohán, O ^{[1
]}

De la Vieja, A ^{[1
]}

Ginter, CS ^{[1
]}

Carrasco, N ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(01)01904-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

引用

页码：490 / 496

页数：7

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