ABC proteins and antibiotic drug resistance: is it all about transport?

被引：38

作者：

Kerr, ID ^{[1
]}

Reynolds, ED

Cove, JH

机构：

[1] Univ Nottingham, Queens Med Ctr, Sch Biomed Sci, Nottingham HG7 2UH, England

[2] Univ Leeds, Sch Biochem & Microbiol, Leeds LS2 9JT, W Yorkshire, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

ATP-binding-cassette protein (ABC protein); lincosamide; macrolide; membrane transport; ribosome protection; streptogramin;

D O I：

10.1042/BST0331000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The precise mechanism of antibiotic-resistance-conferring ABC (ATP-binding-cassette) proteins (termed NBD2) remains open to debate. Currently, two hypotheses are recognized. In one, the NBD2 proteins are envisaged to act at the ribosome to impair antibiotic access to the target site on the 23 S rRNA. In the other, NBD2 proteins are believed to act as the components of ATP driven efflux pumps by associating with membrane spanning proteins capable of binding and transporting antibiotics. Pertinent data in support of these two hypotheses are discussed in this paper.

引用

页码：1000 / 1002

页数：3

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